AMPDB_946 | Lantibiotic nisin-U

PEPTIDE SUMMARY

Lantibiotic nisin-U

1 General Description

AMPDB ID: AMPDB_946

Protein Names: Lantibiotic nisin-U

Protein Family: Type A lantibiotic family

Gene Name: nsuA

Source Organism: Streptococcus uberis

Protein Length: 55 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MNNEDFNLDLIKISKENNSGASPRITSKSLCTPGCKTGILMTCPLKTATCGCHFG

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 2, 'R': 1, 'N': 5, 'D': 2, 'C': 5, 'Q': 0, 'E': 2, 'G': 5, 'H': 1, 'I': 4, 'L': 5, 'K': 5, 'M': 2, 'F': 2, 'P': 3, 'S': 5, 'T': 6, 'W': 0, 'Y': 0, 'V': 0

Frequencies of Amino Acids

'A': 3.64%, 'R': 1.82%, 'N': 9.09%, 'D': 3.64%, 'C': 9.09%, 'Q': 0%, 'E': 3.64%, 'G': 9.09%, 'H': 1.82%, 'I': 7.27%, 'L': 9.09%, 'K': 9.09%, 'M': 3.64%, 'F': 3.64%, 'P': 5.45%, 'S': 9.09%, 'T': 10.91%, 'W': 0%, 'Y': 0%, 'V': 0%

Missing Amino Acid(s)

Q, V, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

H, R

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	5862.8 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	67.455	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	25.755	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.204	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.391	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	8.217	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	1.782	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.2, 0.327, 0.2 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.036	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 250	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Positive Bacteria

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Lantibiotic, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Wirawan RE, Klesse NA, Jack RW, et al. Molecular and genetic characterization of a novel nisin variant produced by Streptococcus uberis. Appl Environ Microbiol. 2006;72(2):1148-56. Published 2006 Feb. doi:10.1128/AEM.72.2.1148-1156.2006

PMID: 16461661

5.2 Protein Sequence Databases

UniProt: Q2QBT0

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: Q2QBT0

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	DQ146939	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR006079

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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