AMPDB_914 | L-amino-acid oxidase

PEPTIDE SUMMARY

L-amino-acid oxidase

1 General Description

AMPDB ID: AMPDB_914

Protein Names: L-amino-acid oxidase (EC 1.4.3.2) (Antiparasitic protein) (APP) (Serum L-amino-acid oxidase) (SR-LAAO)

Protein Family: Flavin monoamine oxidase family; FIG1 subfamily

Gene Name: Nil

Source Organism: Siganus canaliculatus (White-spotted spinefoot) (Chaetodon canaliculatus)

Protein Length: 527 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MDLHRAPWKSSAAAAVLLLALFSGAAASSVEKNLAACLRDNDYDQLLQTVQDGLPHINTSNHVVIVGAGVAGLTAAKLLQDAGHRVTIVEANSRIGGRVETYRNKEEGWYADLGAMRIPSDHSIFRWFAKTLGVKLNPFIMDDHNTFYFVNGLLKRTYTVEANPDILNYKVRSSEKGKSANTLFQDALQKVKDEVEAHGCRAALMKYDKYSAKEYLKEVAGLSSEALRMIGDLLNEQSLMYTALSEMIYDQADVNDNVQYDEVTGGTDLFPRAFLSVLDVPILLNSKVQRIRRSRDGVTVSFKESQRSSLTDLHADMVLVTTTAKAALYMDFEPSLSIRKMEALRAVHYDSSTKIILTFSSRFWEEDGIRGGKSITDRPSRYIYYPSHTFPANSSVGVLLASYTWSDDSLLLQAASDEELKEMALRDLVKIHGERVRALCTGVVVKKWSLDPYSFGAFALFTPYQHLEYAKELFRSEGRVHFAGEHTAFPHAWMESAMKSAIRAATNINKQTLLNEGMNECPAPDEL

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 55, 'R': 30, 'N': 21, 'D': 34, 'C': 4, 'Q': 14, 'E': 32, 'G': 29, 'H': 15, 'I': 21, 'L': 57, 'K': 29, 'M': 14, 'F': 20, 'P': 16, 'S': 44, 'T': 28, 'W': 7, 'Y': 21, 'V': 36

Frequencies of Amino Acids

'A': 10.44%, 'R': 5.69%, 'N': 3.98%, 'D': 6.45%, 'C': 0.76%, 'Q': 2.66%, 'E': 6.07%, 'G': 5.5%, 'H': 2.85%, 'I': 3.98%, 'L': 10.82%, 'K': 5.5%, 'M': 2.66%, 'F': 3.8%, 'P': 3.04%, 'S': 8.35%, 'T': 5.31%, 'W': 1.33%, 'Y': 3.98%, 'V': 6.83%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

255

Hydrophilic Amino Acid(s) Count

272

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	58810.8 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	87.97	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	44.467	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.23	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.721	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	6.572	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-5.841	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.307, 0.209, 0.3 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.091	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	69790, 70040	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

C.irritans, S.aureus (Gram-positive), T.brucei, V.cholerae (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-parasitic, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Oxidoreductase

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Wang F, Li R, Xie M, et al. The serum of rabbitfish (Siganus oramin) has antimicrobial activity to some pathogenic organisms and a novel serum L-amino acid oxidase is isolated. Fish Shellfish Immunol. 2011;30(4-5):1095-108. Published 2011 Apr-May. doi:10.1016/j.fsi.2011.02.004

PMID: 21333741

Citation 2: Wang FH, Xie MQ, Li AX, et al. A novel protein isolated from the serum of rabbitfish (Siganus oramin) is lethal to Cryptocaryon irritans. Fish Shellfish Immunol. 2010;29(1):32-41. Published 2010 Jul. doi:10.1016/j.fsi.2010.01.006

PMID: 20117218

5.2 Protein Sequence Databases

UniProt: P86810

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P86810

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	HQ540313	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR002937, IPR036188, IPR001613

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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