AMPDB_889 | Defensin
PEPTIDE SUMMARY
Defensin
1 General Description
AMPDB ID: AMPDB_889
Protein Names: Defensin (Galiomicin)
Protein Family: Invertebrate defensin family; Type 2 subfamily
Gene Name: Nil
Protein Length: 72 AA
Protein Existence: Evidence at protein level
2 Protein Sequence & Composition
2.1 Sequence
MAKNFQSVLLLVCLSFLVIVSSPQNAVQADTLIGSCVWGATNYTSDCNAECKRRGYKGGHCGSFLNVNCWCE
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 5, 'R': 2, 'N': 6, 'D': 2, 'C': 7, 'Q': 3, 'E': 2, 'G': 6, 'H': 1, 'I': 2, 'L': 7, 'K': 3, 'M': 1, 'F': 3, 'P': 1, 'S': 7, 'T': 3, 'W': 2, 'Y': 2, 'V': 7
Frequencies of Amino Acids
'A': 6.94%, 'R': 2.78%, 'N': 8.33%, 'D': 2.78%, 'C': 9.72%, 'Q': 4.17%, 'E': 2.78%, 'G': 8.33%, 'H': 1.39%, 'I': 2.78%, 'L': 9.72%, 'K': 4.17%, 'M': 1.39%, 'F': 4.17%, 'P': 1.39%, 'S': 9.72%, 'T': 4.17%, 'W': 2.78%, 'Y': 2.78%, 'V': 9.72%
Missing Amino Acid(s)
No Amino Acid(s) are missing in this protein
Most Occurring Amino Acid(s)
C, L, S, V
Less Occurring Amino Acid(s)
H, M, P
Hydrophobic Amino Acid(s) Count
34
Hydrophilic Amino Acid(s) Count
38
Basic Amino Acid(s) Count
4
Acidic Amino Acid(s) Count
6
Modified Amino Acid(s) Count
0
Modified Amino Acid(s) Frequencies
0
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 7823 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 83.889 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 42.518 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) 0.226 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.548 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 7.691 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) 0.657 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.319, 0.278, 0.208 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.097 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 13980, 14355 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
A.niger, C.albicans, C.fructus, E.coli (Gram-negative), F.oxysporum, L.monocytogenes (Gram-positive), M.luteus (Gram-negative), P.pastoris, P.tannophilus, S.aureus (Gram-positive), S.lutea (Gram-negative), T.harzianum
4.2 Antimicrobial Activity
Antimicrobial, Defensin, Fungicide, Anti-candida, Anti-gram-negative, Anti-gram-Positive
4.3 Enzymatic Activity
Not found
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Non-hemolytic, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: Lee YS, Yun EK, Jang WS, et al. Purification, cDNA cloning and expression of an insect defensin from the great wax moth, Galleria mellonella. Insect Mol Biol. 2004;13(1):65-72. Published 2004 Feb. doi:10.1111/j.1365-2583.2004.00462.x
PMID: 14728668
Citation 2: Cytryńska M, Mak P, Zdybicka-Barabas A, et al. Purification and characterization of eight peptides from Galleria mellonella immune hemolymph. Peptides. 2007;28(3):533-46. Published 2007 Mar. doi:10.1016/j.peptides.2006.11.010
PMID: 17194500
Citation 3: Stączek S, Zdybicka-Barabas A, Wojda I, et al. Fungal α-1,3-Glucan as a New Pathogen-Associated Molecular Pattern in the Insect Model Host Galleria mellonella. Molecules. 2021;26(16). Published 2021 Aug 23. doi:10.3390/molecules26165097
PMID: 34443685
5.2 Protein Sequence Databases
UniProt: P85213
5.3 3D Structure Databases
No PDB Ids found
AlphaFoldDB: P85213
5.4 Nucleotide Sequence Databases
Sl. no. Accession(s) Access Link(s)
1. AY528421 GenBank || EMBL
CCDS: Not found
RefSeq: Not found
5.5 Protein-Protein Interaction Databases
STRING: Not found
IntAct: Not found
MINT: Not found
DIP: Not found
BioGRID: Not found
5.6 Ligand Databases
BindingDB: Not found
DrugBank: Not found
ChEMBL: Not found
5.7 Family & Domain Databases
PANTHER: Not found
PROSITE: PS51378
5.8 Genome Annotation Databases
Ensembl: Not found
KEGG: Not found
5.9 Phylogenomic Databases
GeneTree: Not found
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: Not found




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