AMPDB_869 | Histone H1

PEPTIDE SUMMARY

Histone H1

1 General Description

AMPDB ID: AMPDB_869

Protein Names: Histone H1 [Cleaved into: SAMP H1]

Protein Family: Histone H1 H5 family

Gene Name: Nil

Source Organism: Salmo salar (Atlantic salmon)

Protein Length: 55 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MAEVAPAPAAAAPAKAPKKKAAAKPKKAGPSVGELIVKAVSASKERSGVSLAALK

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 17, 'R': 1, 'N': 0, 'D': 0, 'C': 0, 'Q': 0, 'E': 3, 'G': 3, 'H': 0, 'I': 1, 'L': 3, 'K': 10, 'M': 1, 'F': 0, 'P': 6, 'S': 5, 'T': 0, 'W': 0, 'Y': 0, 'V': 5

Frequencies of Amino Acids

'A': 30.91%, 'R': 1.82%, 'N': 0%, 'D': 0%, 'C': 0%, 'Q': 0%, 'E': 5.45%, 'G': 5.45%, 'H': 0%, 'I': 1.82%, 'L': 5.45%, 'K': 18.18%, 'M': 1.82%, 'F': 0%, 'P': 10.91%, 'S': 9.09%, 'T': 0%, 'W': 0%, 'Y': 0%, 'V': 9.09%

Missing Amino Acid(s)

C, D, F, H, N, Q, T, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

I, M, R

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	5320.37 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	85.636	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	40.169	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.011	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.531	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	11.16	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	8	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.164, 0.255, 0.436 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 0	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

A.salmonicida (Gram-negative), B.subtilis (Gram-positive), E.coli (Gram-negative), S.typhimurium, V.anguillarum (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: LÃ¼ders T, Birkemo GA, Nissen-Meyer J, et al. Proline conformation-dependent antimicrobial activity of a proline-rich histone h1 N-terminal Peptide fragment isolated from the skin mucus of Atlantic salmon. Antimicrob Agents Chemother. 2005;49(6):2399-406. Published 2005 Jun. doi:10.1128/AAC.49.6.2399-2406.2005

PMID: 15917539

5.2 Protein Sequence Databases

UniProt: P84408

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P84408

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AJ877042	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR005818, IPR036388

PANTHER: Not found

PROSITE: PS51504

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

Download