AMPDB_860 | Ranacyclin-T

PEPTIDE SUMMARY

Ranacyclin-T

1 General Description

AMPDB ID: AMPDB_860

Protein Names: Ranacyclin-T

Protein Family: Frog skin active peptide (FSAP) family; Brevinin subfamily

Gene Name: RNCT

Source Organism: Rana temporaria (European common frog)

Protein Length: 62 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MFTMKKTLLVLFFLGVVSLSLCVEERDADEEDGGEVMEEEVKRGALRGCWTKSYPPKPCKGK

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 2, 'R': 3, 'N': 0, 'D': 3, 'C': 3, 'Q': 0, 'E': 8, 'G': 6, 'H': 0, 'I': 0, 'L': 7, 'K': 7, 'M': 3, 'F': 3, 'P': 3, 'S': 3, 'T': 3, 'W': 1, 'Y': 1, 'V': 6

Frequencies of Amino Acids

'A': 3.23%, 'R': 4.84%, 'N': 0%, 'D': 4.84%, 'C': 4.84%, 'Q': 0%, 'E': 12.9%, 'G': 9.68%, 'H': 0%, 'I': 0%, 'L': 11.29%, 'K': 11.29%, 'M': 4.84%, 'F': 4.84%, 'P': 4.84%, 'S': 4.84%, 'T': 4.84%, 'W': 1.61%, 'Y': 1.61%, 'V': 9.68%

Missing Amino Acid(s)

H, I, N, Q

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

W, Y

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	6983.18 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	75.323	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	37.279	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.261	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.621	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	5.068	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-1.175	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.29, 0.194, 0.323 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.081	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	6990, 7115	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

B.megaterium, C.albicans, C.tropicalis (Gram-negative), E.coli (Gram-negative), M.luteus (Gram-negative), P.nicotianae (Gram-positive), P.syringae (Gram-negative), Y.pseudotuberculosis (Gram-negative)

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Fungicide, Anti-candida, Anti-tuberculosis, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytolysis, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Mangoni ML, Papo N, Mignogna G, et al. Ranacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action, and parameters involved in target specificity. Biochemistry. 2003;42(47):14023-35. Published 2003 Dec 2. doi:10.1021/bi034521l

PMID: 14636071

5.2 Protein Sequence Databases

UniProt: P83719

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P83719

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AJ583866	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR004275, IPR032019

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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