AMPDB_854 | Antifungal peptide 2

PEPTIDE SUMMARY

Antifungal peptide 2

1 General Description

AMPDB ID: AMPDB_854

Protein Names: Antifungal peptide 2 (EAFP2)

Protein Family: Nil

Gene Name: Nil

Source Organism: Eucommia ulmoides (Hardy rubber tree)

Protein Length: 41 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

QTCASRCPRPCNAGLCCSIYGYCGSGAAYCGAGNCRCQCRG

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 5, 'R': 4, 'N': 2, 'D': 0, 'C': 10, 'Q': 2, 'E': 0, 'G': 7, 'H': 0, 'I': 1, 'L': 1, 'K': 0, 'M': 0, 'F': 0, 'P': 2, 'S': 3, 'T': 1, 'W': 0, 'Y': 3, 'V': 0

Frequencies of Amino Acids

'A': 12.2%, 'R': 9.76%, 'N': 4.88%, 'D': 0%, 'C': 24.39%, 'Q': 4.88%, 'E': 0%, 'G': 17.07%, 'H': 0%, 'I': 2.44%, 'L': 2.44%, 'K': 0%, 'M': 0%, 'F': 0%, 'P': 4.88%, 'S': 7.32%, 'T': 2.44%, 'W': 0%, 'Y': 7.32%, 'V': 0%

Missing Amino Acid(s)

D, E, F, H, K, M, V, W

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

I, L, T

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	4185.8 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	31.22	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	3.366	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.066	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.527	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	8.258	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	3.376	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.122, 0.341, 0.146 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.073	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	4470, 5095	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

A.lycopersici, F.oxysporum, P.infestans, V.dahliae

4.2 Antimicrobial Activity

Antimicrobial, Fungicide, Plant defense

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Huang RH, Xiang Y, Liu XZ, et al. Two novel antifungal peptides distinct with a five-disulfide motif from the bark of Eucommia ulmoides Oliv. FEBS Lett. 2002;521(1-3):87-90. Published 2002 Jun 19. doi:10.1016/s0014-5793(02)02829-6

PMID: 12067732

Citation 2: Huang RH, Xiang Y, Tu GZ, et al. Solution structure of Eucommia antifungal peptide: a novel structural model distinct with a five-disulfide motif. Biochemistry. 2004;43(20):6005-12. Published 2004 May 25. doi:10.1021/bi036263y

PMID: 15147184

Citation 3: Xiang Y, Huang RH, Liu XZ, et al. Crystal structure of a novel antifungal protein distinct with five disulfide bridges from Eucommia ulmoides Oliver at an atomic resolution. J Struct Biol. 2004;148(1):86-97. Published 2004 Oct. doi:10.1016/j.jsb.2004.04.002

PMID: 15363789

5.2 Protein Sequence Databases

UniProt: P83597

5.3 3D Structure Databases

	Sl. no.	PDB ID	Method	Resolution	Access Links	3D View

AlphaFoldDB: P83597

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR001002, IPR018371, IPR036861

PANTHER: Not found

PROSITE: PS00026, PS50941

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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