AMPDB_832 | Moricin-1

PEPTIDE SUMMARY

Moricin-1

1 General Description

AMPDB ID: AMPDB_832

Protein Names: Moricin-1

Protein Family: Moricin family

Gene Name: MOR1 MOR

Source Organism: Bombyx mori (Silk moth)

Protein Length: 66 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MNILKFFFVFIVAMSLVSCSTAAPAKIPIKAIKTVGKAVGKGLRAINIASTANDVFNFLKPKKRKH

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 9, 'R': 2, 'N': 4, 'D': 1, 'C': 1, 'Q': 0, 'E': 0, 'G': 3, 'H': 1, 'I': 7, 'L': 4, 'K': 10, 'M': 2, 'F': 6, 'P': 3, 'S': 4, 'T': 3, 'W': 0, 'Y': 0, 'V': 6

Frequencies of Amino Acids

'A': 13.64%, 'R': 3.03%, 'N': 6.06%, 'D': 1.52%, 'C': 1.52%, 'Q': 0%, 'E': 0%, 'G': 4.55%, 'H': 1.52%, 'I': 10.61%, 'L': 6.06%, 'K': 15.15%, 'M': 3.03%, 'F': 9.09%, 'P': 4.55%, 'S': 6.06%, 'T': 4.55%, 'W': 0%, 'Y': 0%, 'V': 9.09%

Missing Amino Acid(s)

E, Q, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

C, D, H

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	7162.75 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	105	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	33.367	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.473	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.748	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	11.647	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	11.024	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.348, 0.212, 0.227 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.091	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 0	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria and Gram Positive Bacteria

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Furukawa S, Tanaka H, Nakazawa H, et al. Inducible gene expression of moricin, a unique antibacterial peptide from the silkworm (Bombyx mori). Biochem J. 1999;340 ( Pt 1)(Pt 1):265-71. Published 1999 May 15. doi:

PMID: 10229682

Citation 2: Hara S, Yamakawa M, Yamakawa M. Moricin, a novel type of antibacterial peptide isolated from the silkworm, Bombyx mori. J Biol Chem. 1995;270(50):29923-7. Published 1995 Dec 15. doi:10.1074/jbc.270.50.29923

PMID: 8530391

Citation 3: Hemmi H, Ishibashi J, Hara S, et al. Solution structure of moricin, an antibacterial peptide, isolated from the silkworm Bombyx mori. FEBS Lett. 2002;518(1-3):33-8. Published 2002 May 8. doi:10.1016/s0014-5793(02)02637-6

PMID: 11997013

5.2 Protein Sequence Databases

UniProt: P82818

5.3 3D Structure Databases

	Sl. no.	PDB ID	Method	Resolution	Access Links	3D View

AlphaFoldDB: P82818

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AB006915	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: 7091.BGIBMGA011495-TA

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR009456, IPR037043

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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