AMPDB_831 | Cecropin-A
PEPTIDE SUMMARY
Cecropin-A
1 General Description
AMPDB ID: AMPDB_831
Protein Names: Cecropin-A
Protein Family: Cecropin family
Gene Name: CECA AAEL000627
Protein Length: 59 AA
Protein Existence: Evidence at protein level
2 Protein Sequence & Composition
2.1 Sequence
MNFTKLFLLIAMAVLLLTGQSEAGGLKKLGKKLEGAGKRVFNAAEKALPVVAGAKALGK
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 10, 'R': 1, 'N': 2, 'D': 0, 'C': 0, 'Q': 1, 'E': 3, 'G': 8, 'H': 0, 'I': 1, 'L': 11, 'K': 9, 'M': 2, 'F': 3, 'P': 1, 'S': 1, 'T': 2, 'W': 0, 'Y': 0, 'V': 4
Frequencies of Amino Acids
'A': 16.95%, 'R': 1.69%, 'N': 3.39%, 'D': 0%, 'C': 0%, 'Q': 1.69%, 'E': 5.08%, 'G': 13.56%, 'H': 0%, 'I': 1.69%, 'L': 18.64%, 'K': 15.25%, 'M': 3.39%, 'F': 5.08%, 'P': 1.69%, 'S': 1.69%, 'T': 3.39%, 'W': 0%, 'Y': 0%, 'V': 6.78%
Missing Amino Acid(s)
C, D, H, W, Y
Most Occurring Amino Acid(s)
L
Less Occurring Amino Acid(s)
I, P, Q, R, S
Hydrophobic Amino Acid(s) Count
40
Hydrophilic Amino Acid(s) Count
19
Basic Amino Acid(s) Count
3
Acidic Amino Acid(s) Count
10
Modified Amino Acid(s) Count
0
Modified Amino Acid(s) Frequencies
0
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 6083.42 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 115.932 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 19.842 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) 0.436 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.729 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 11.094 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) 7.001 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.322, 0.203, 0.441 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.051 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 0, 0 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
A.fumigatus, A.viridans (Gram-positive), B.bassiana, B.cereus (Gram-positive), B.megaterium, B.subtilis (Gram-positive), B.thuringiensis (Gram-positive), C.albicans, C.neoformans, E.cloacae (Gram-negative), E.coli (Gram-negative), F.culmorum, F.oxysporum, K.pneumoniae (Gram-negative), L.monocytogenes (Gram-positive), M.luteus (Gram-negative), N.crassa, P.aeruginosa (Gram-negative), S.aureus (Gram-positive), S.marcescens (Gram-negative), S.typhimurium, X.campestris (Gram-negative)
4.2 Antimicrobial Activity
Antibiotic, Antimicrobial, Fungicide, Anti-candida, Anti-yeast, Anti-gram-negative, Anti-gram-Positive
4.3 Enzymatic Activity
Not found
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Non-hemolytic, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: Lowenberger C, Charlet M, Vizioli J, et al. Antimicrobial activity spectrum, cDNA cloning, and mRNA expression of a newly isolated member of the cecropin family from the mosquito vector Aedes aegypti. J Biol Chem. 1999;274(29):20092-7. Published 1999 Jul 16. doi:10.1074/jbc.274.29.20092
PMID: 10400619
Citation 2: Nene V, Wortman JR, Lawson D, et al. Genome sequence of Aedes aegypti, a major arbovirus vector. Science. 2007;316(5832):1718-23. Published 2007 Jun 22. doi:10.1126/science.1138878
PMID: 17510324
5.2 Protein Sequence Databases
UniProt: P82592
5.3 3D Structure Databases
No PDB Ids found
AlphaFoldDB: P82592
5.4 Nucleotide Sequence Databases
Sl. no. Accession(s) Access Link(s)
1. AF117886 GenBank || EMBL
2. AY064080 GenBank || EMBL
3. AY064081 GenBank || EMBL
4. AF387488 GenBank || EMBL
5. CH477197 GenBank || EMBL
CCDS: Not found
5.5 Protein-Protein Interaction Databases
STRING: Not found
IntAct: Not found
MINT: Not found
DIP: Not found
BioGRID: Not found
5.6 Ligand Databases
BindingDB: Not found
DrugBank: Not found
ChEMBL: Not found
5.7 Family & Domain Databases
InterPro: IPR000875, IPR020400
PANTHER: PTHR38329
PROSITE: Not found
5.8 Genome Annotation Databases
Ensembl: Not found
KEGG: Not found
5.9 Phylogenomic Databases
GeneTree: Not found
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: Not found




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