AMPDB_825 | Defensin alpha 4

PEPTIDE SUMMARY

Defensin alpha 4

1 General Description

AMPDB ID: AMPDB_825

Protein Names: Defensin alpha 4 (Neutrophil defensin 4) (RMAD-4) [Cleaved into: Defensin alpha 5 (Neutrophil defensin 5) (RMAD-5)]

Protein Family: Alpha-defensin family

Gene Name: Nil

Source Organism: Macaca mulatta (Rhesus macaque)

Protein Length: 94 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MRTIAILAAILLFALLAQAKSLQETADDAATQEQPGEDDQDLAVSFEENGLSTLRASGSQARRTCRCRFGRCFRRESYSGSCNINGRIFSLCCR

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 12, 'R': 11, 'N': 3, 'D': 5, 'C': 6, 'Q': 6, 'E': 6, 'G': 6, 'H': 0, 'I': 5, 'L': 10, 'K': 1, 'M': 1, 'F': 5, 'P': 1, 'S': 9, 'T': 5, 'W': 0, 'Y': 1, 'V': 1

Frequencies of Amino Acids

'A': 12.77%, 'R': 11.7%, 'N': 3.19%, 'D': 5.32%, 'C': 6.38%, 'Q': 6.38%, 'E': 6.38%, 'G': 6.38%, 'H': 0%, 'I': 5.32%, 'L': 10.64%, 'K': 1.06%, 'M': 1.06%, 'F': 5.32%, 'P': 1.06%, 'S': 9.57%, 'T': 5.32%, 'W': 0%, 'Y': 1.06%, 'V': 1.06%

Missing Amino Acid(s)

H, W

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

K, M, P, V, Y

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	10352.7 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	78.085	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	53.19	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.236	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.8	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	7.734	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	0.638	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.234, 0.202, 0.309 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.064	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	1490, 1865	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

C.neoformans, E.coli (Gram-negative), L.monocytogenes (Gram-positive), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Defensin, Fungicide, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Tang YQ, Yuan J, Miller CJ, et al. Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes. Infect Immun. 1999;67(11):6139-44. Published 1999 Nov. doi:10.1128/IAI.67.11.6139-6144.1999

PMID: 10531277

5.2 Protein Sequence Databases

UniProt: P82319

5.3 3D Structure Databases

	Sl. no.	PDB ID	Method	Resolution	Access Links	3D View

AlphaFoldDB: P82319

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AF188271	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR016327, IPR006081, IPR002366, IPR006080

PANTHER: PTHR11876

PROSITE: PS00269

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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