AMPDB_823 | Cathelicidin-2

PEPTIDE SUMMARY

Cathelicidin-2

1 General Description

AMPDB ID: AMPDB_823

Protein Names: Cathelicidin-2 (Bactenecin-5) (Bac5) (ChBac5)

Protein Family: Cathelicidin family

Gene Name: CATHL2 BAC5

Source Organism: Capra hircus (Goat)

Protein Length: 176 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

METQGASLSLGRWSLWLLLLGLVVPLASAQALSYREAVLRAVGQLNERSSEANLYRLLELDPAPNDEVDPGTRKPVSFTVKETVCPRTTQQPPEECDFKENGLVKQCVGTVTLDPSNDQFDINCNELQSVRFRPPIRRPPIRPPFNPPFRPPVRPPFRPPFRPPFRPPIGPFPGRR

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 8, 'R': 19, 'N': 8, 'D': 7, 'C': 4, 'Q': 8, 'E': 11, 'G': 9, 'H': 0, 'I': 4, 'L': 19, 'K': 4, 'M': 1, 'F': 10, 'P': 29, 'S': 10, 'T': 8, 'W': 2, 'Y': 2, 'V': 13

Frequencies of Amino Acids

'A': 4.55%, 'R': 10.8%, 'N': 4.55%, 'D': 3.98%, 'C': 2.27%, 'Q': 4.55%, 'E': 6.25%, 'G': 5.11%, 'H': 0%, 'I': 2.27%, 'L': 10.8%, 'K': 2.27%, 'M': 0.57%, 'F': 5.68%, 'P': 16.48%, 'S': 5.68%, 'T': 4.55%, 'W': 1.14%, 'Y': 1.14%, 'V': 7.39%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	19845.8 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	76.932	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	66.106	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.506	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.699	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.438	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	4.77	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.284, 0.318, 0.222 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.08	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	13980, 14230	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative), L.monocytogenes (Gram-positive), S.aureus (Gram-positive), S.typhimurium

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Shamova O, Brogden KA, Zhao C, et al. Purification and properties of proline-rich antimicrobial peptides from sheep and goat leukocytes. Infect Immun. 1999;67(8):4106-11. Published 1999 Aug. doi:10.1128/IAI.67.8.4106-4111.1999

PMID: 10417180

5.2 Protein Sequence Databases

UniProt: P82018

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P82018

5.4 Nucleotide Sequence Databases