AMPDB_816 | Dermaseptin-B4

PEPTIDE SUMMARY

Dermaseptin-B4

1 General Description

AMPDB ID: AMPDB_816

Protein Names: Dermaseptin-B4 (DRS-B4) (Dermaseptin BIV)

Protein Family: Frog skin active peptide (FSAP) family; Dermaseptin subfamily

Gene Name: Nil

Source Organism: Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)

Protein Length: 76 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MAFLKKSLFLVLFLGLVSLSICEEEKRENKDEIEQEDDEQSEEKRALWKDILKNVGKAAGKAVLNTVTDMVNQGEQ

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 5, 'R': 2, 'N': 4, 'D': 5, 'C': 1, 'Q': 4, 'E': 11, 'G': 4, 'H': 0, 'I': 3, 'L': 10, 'K': 9, 'M': 2, 'F': 3, 'P': 0, 'S': 4, 'T': 2, 'W': 1, 'Y': 0, 'V': 6

Frequencies of Amino Acids

'A': 6.58%, 'R': 2.63%, 'N': 5.26%, 'D': 6.58%, 'C': 1.32%, 'Q': 5.26%, 'E': 14.47%, 'G': 5.26%, 'H': 0%, 'I': 3.95%, 'L': 13.16%, 'K': 11.84%, 'M': 2.63%, 'F': 3.95%, 'P': 0%, 'S': 5.26%, 'T': 2.63%, 'W': 1.32%, 'Y': 0%, 'V': 7.89%

Missing Amino Acid(s)

H, P, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

C, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	8641.87 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	96.184	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	61.204	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.458	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.732	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	4.401	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-5.045	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.303, 0.158, 0.368 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.053	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	5500, 5500	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria and Gram Positive Bacteria

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Charpentier S, Amiche M, Mester J, et al. Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics. J Biol Chem. 1998;273(24):14690-7. Published 1998 Jun 12. doi:10.1074/jbc.273.24.14690

PMID: 9614066

Citation 2: Amiche M, Ladram A, Nicolas P, et al. A consistent nomenclature of antimicrobial peptides isolated from frogs of the subfamily Phyllomedusinae. Peptides. 2008;29(11):2074-82. Published 2008 Nov. doi:10.1016/j.peptides.2008.06.017

PMID: 18644413

5.2 Protein Sequence Databases

UniProt: P81486

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P81486

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	Y16565	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR022731, IPR004275, IPR016322

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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