AMPDB_795 | Protonectin

PEPTIDE SUMMARY

Protonectin

1 General Description

AMPDB ID: AMPDB_795

Protein Names: Protonectin (Agelaia-chemotactic peptide) (Agelaia-CP)

Protein Family: MCD family; Protonectin subfamily

Gene Name: Nil

Source Organism: Agelaia pallipes pallipes (Neotropical social wasp)

Protein Length: 12 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

ILGTILGLLKGL

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 0, 'R': 0, 'N': 0, 'D': 0, 'C': 0, 'Q': 0, 'E': 0, 'G': 3, 'H': 0, 'I': 2, 'L': 5, 'K': 1, 'M': 0, 'F': 0, 'P': 0, 'S': 0, 'T': 1, 'W': 0, 'Y': 0, 'V': 0

Frequencies of Amino Acids

'A': 0%, 'R': 0%, 'N': 0%, 'D': 0%, 'C': 0%, 'Q': 0%, 'E': 0%, 'G': 25%, 'H': 0%, 'I': 16.67%, 'L': 41.67%, 'K': 8.33%, 'M': 0%, 'F': 0%, 'P': 0%, 'S': 0%, 'T': 8.33%, 'W': 0%, 'Y': 0%, 'V': 0%

Missing Amino Acid(s)

A, C, D, E, F, H, M, N, P, Q, R, S, V, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

K, T

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	1210.57 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	227.5	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	20.042	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	1.85	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.379	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.7	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	0.998	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.583, 0.25, 0.417 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 0	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

B.subtilis (Gram-positive), E.coli (Gram-negative), P.aeruginosa (Gram-negative), S.aureus (Gram-positive), S.epidermis

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Mendes MA, Monson de Souza B, Delazari dos Santos L, et al. Structural characterization of novel chemotactic and mastoparan peptides from the venom of the social wasp Agelaiapallipes pallipes by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2004;18(6):636-42. Published 2004. doi:10.1002/rcm.1382

PMID: 15052574

Citation 2: Mendes MA, de Souza BM, Marques MR, et al. Structural and biological characterization of two novel peptides from the venom of the neotropical social wasp Agelaia pallipes pallipes. Toxicon. 2004;44(1):67-74. Published 2004 Jul. doi:10.1016/j.toxicon.2004.04.009

PMID: 15225564

Citation 3: Wang K, Dang W, Yan J, et al. Membrane perturbation action mode and structure-activity relationships of Protonectin, a novel antimicrobial peptide from the venom of the neotropical social wasp Agelaia pallipes pallipes. Antimicrob Agents Chemother. 2013;57(10):4632-9. Published 2013 Oct. doi:10.1128/AAC.02311-12

PMID: 23836163

5.2 Protein Sequence Databases

UniProt: P69437

5.3 3D Structure Databases

	Sl. no.	PDB ID	Method	Resolution	Access Links	3D View

AlphaFoldDB: P69437

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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