AMPDB_752 | Beta-defensin 7

PEPTIDE SUMMARY

Beta-defensin 7

1 General Description

AMPDB ID: AMPDB_752

Protein Names: Beta-defensin 7 (BNBD-7) (BNDB-7)

Protein Family: Beta-defensin family

Gene Name: DEFB7

Source Organism: Bos taurus (Bovine)

Protein Length: 62 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MRLHHLLLALLFLVLSAGSGFTQGVRNFVTCRINRGFCVPIRCPGHRRQIGTCLGPRIKCCR

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 2, 'R': 9, 'N': 2, 'D': 0, 'C': 6, 'Q': 2, 'E': 0, 'G': 7, 'H': 3, 'I': 4, 'L': 9, 'K': 1, 'M': 1, 'F': 4, 'P': 3, 'S': 2, 'T': 3, 'W': 0, 'Y': 0, 'V': 4

Frequencies of Amino Acids

'A': 3.23%, 'R': 14.52%, 'N': 3.23%, 'D': 0%, 'C': 9.68%, 'Q': 3.23%, 'E': 0%, 'G': 11.29%, 'H': 4.84%, 'I': 6.45%, 'L': 14.52%, 'K': 1.61%, 'M': 1.61%, 'F': 6.45%, 'P': 4.84%, 'S': 3.23%, 'T': 4.84%, 'W': 0%, 'Y': 0%, 'V': 6.45%

Missing Amino Acid(s)

D, E, W, Y

Most Occurring Amino Acid(s)

L, R

Less Occurring Amino Acid(s)

K, M

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	6964.45 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	103.71	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	20.727	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.345	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.761	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	11.974	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	9.899	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.339, 0.226, 0.194 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.065	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 375	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Defensin, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Selsted ME, Tang YQ, Morris WL, et al. Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils. J Biol Chem. 1993;268(9):6641-8. Published 1993 Mar 25. doi:

PMID: 8454635

5.2 Protein Sequence Databases

UniProt: P46165

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P46165

5.4 Nucleotide Sequence Databases