AMPDB_750 | Beta-defensin 4

PEPTIDE SUMMARY

Beta-defensin 4

1 General Description

AMPDB ID: AMPDB_750

Protein Names: Beta-defensin 4 (BNBD-4) (BNDB-4)

Protein Family: Beta-defensin family

Gene Name: DEFB4 BNBD4

Source Organism: Bos taurus (Bovine)

Protein Length: 63 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MRLHHLLLAVLFLVLSAGSGFTQRVRNPQSCRWNMGVCIPFLCRVGMRQIGTCFGPRVPCCRR

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 2, 'R': 9, 'N': 2, 'D': 0, 'C': 6, 'Q': 3, 'E': 0, 'G': 6, 'H': 2, 'I': 2, 'L': 8, 'K': 0, 'M': 3, 'F': 4, 'P': 4, 'S': 3, 'T': 2, 'W': 1, 'Y': 0, 'V': 6

Frequencies of Amino Acids

'A': 3.17%, 'R': 14.29%, 'N': 3.17%, 'D': 0%, 'C': 9.52%, 'Q': 4.76%, 'E': 0%, 'G': 9.52%, 'H': 3.17%, 'I': 3.17%, 'L': 12.7%, 'K': 0%, 'M': 4.76%, 'F': 6.35%, 'P': 6.35%, 'S': 4.76%, 'T': 3.17%, 'W': 1.59%, 'Y': 0%, 'V': 9.52%

Missing Amino Acid(s)

D, E, K, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	7160.69 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	92.698	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	46.727	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.352	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.583	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	11.957	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	8.808	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.333, 0.238, 0.206 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.079	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	5500, 5875	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Defensin, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Selsted ME, Tang YQ, Morris WL, et al. Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils. J Biol Chem. 1993;268(9):6641-8. Published 1993 Mar 25. doi:

PMID: 8454635

5.2 Protein Sequence Databases

UniProt: P46162

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P46162

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	U36200	GenBank \|\| EMBL
2.	AF008307	GenBank \|\| EMBL
3.	AF014107	GenBank \|\| EMBL

CCDS: Not found

RefSeq: NP_777200.1

5.5 Protein-Protein Interaction Databases

STRING: 9913.ENSBTAP00000055285

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR006080, IPR001855

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: ENSGT00940000160995

KEGG: bta:286836

5.9 Phylogenomic Databases

GeneTree: ENSGT00940000160995

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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