AMPDB_743 | Ranalexin

PEPTIDE SUMMARY

Ranalexin

1 General Description

AMPDB ID: AMPDB_743

Protein Names: Ranalexin

Protein Family: Frog skin active peptide (FSAP) family; Brevinin subfamily

Gene Name: Nil

Source Organism: Lithobates catesbeianus (American bullfrog) (Rana catesbeiana)

Protein Length: 66 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MFTLKKSLLLLFFLGTINLSLCEEERNAEEERRDNPDERDVEVEKRFLGGLIKIVPAMICAVTKKC

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 3, 'R': 5, 'N': 3, 'D': 3, 'C': 3, 'Q': 0, 'E': 9, 'G': 3, 'H': 0, 'I': 4, 'L': 10, 'K': 6, 'M': 2, 'F': 4, 'P': 2, 'S': 2, 'T': 3, 'W': 0, 'Y': 0, 'V': 4

Frequencies of Amino Acids

'A': 4.55%, 'R': 7.58%, 'N': 4.55%, 'D': 4.55%, 'C': 4.55%, 'Q': 0%, 'E': 13.64%, 'G': 4.55%, 'H': 0%, 'I': 6.06%, 'L': 15.15%, 'K': 9.09%, 'M': 3.03%, 'F': 6.06%, 'P': 3.03%, 'S': 3.03%, 'T': 4.55%, 'W': 0%, 'Y': 0%, 'V': 6.06%

Missing Amino Acid(s)

H, Q, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

M, P, S

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	7614.98 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	104.848	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	43.503	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.088	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.682	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	5.112	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-1.172	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.333, 0.152, 0.364 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.061	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 125	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytolysis, Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Clark DP, Durell S, Maloy WL, et al. Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin. J Biol Chem. 1994;269(14):10849-55. Published 1994 Apr 8. doi:

PMID: 8144672

Citation 2: Vignal E, Chavanieu A, Roch P, et al. Solution structure of the antimicrobial peptide ranalexin and a study of its interaction with perdeuterated dodecylphosphocholine micelles. Eur J Biochem. 1998;253(1):221-8. Published 1998 Apr 1. doi:10.1046/j.1432-1327.1998.2530221.x

PMID: 9578480

5.2 Protein Sequence Databases

UniProt: P39084

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P39084

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	S69903	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR012520, IPR004275

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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