AMPDB_720 | Antimicrobial peptide 1

PEPTIDE SUMMARY

Antimicrobial peptide 1

1 General Description

AMPDB ID: AMPDB_720

Protein Names: Antimicrobial peptide 1 (MJ-AMP1) (AMP1)

Protein Family: AMP family

Gene Name: AMP1

Source Organism: Mirabilis jalapa (Garden four-o`clock)

Protein Length: 61 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

LPVAFLKFAIVLILFIAMSAMIEAQCIGNGGRCNENVGPPYCCSGFCLRQPGQGYGYCKNR

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 5, 'R': 3, 'N': 4, 'D': 0, 'C': 6, 'Q': 3, 'E': 2, 'G': 8, 'H': 0, 'I': 5, 'L': 5, 'K': 2, 'M': 2, 'F': 4, 'P': 4, 'S': 2, 'T': 0, 'W': 0, 'Y': 3, 'V': 3

Frequencies of Amino Acids

'A': 8.2%, 'R': 4.92%, 'N': 6.56%, 'D': 0%, 'C': 9.84%, 'Q': 4.92%, 'E': 3.28%, 'G': 13.11%, 'H': 0%, 'I': 8.2%, 'L': 8.2%, 'K': 3.28%, 'M': 3.28%, 'F': 6.56%, 'P': 6.56%, 'S': 3.28%, 'T': 0%, 'W': 0%, 'Y': 4.92%, 'V': 4.92%

Missing Amino Acid(s)

D, H, T, W

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

E, K, M, S

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	6604.84 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	86.393	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	38.082	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.413	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.483	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	8.373	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	2.627	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.328, 0.295, 0.23 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.115	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	4470, 4845	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria and Gram Positive Bacteria

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Fungicide, Plant defense, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: De Bolle MF, Eggermont K, Duncan RE, et al. Cloning and characterization of two cDNA clones encoding seed-specific antimicrobial peptides from Mirabilis jalapa L. Plant Mol Biol. 1995;28(4):713-21. Published 1995 Jul. doi:10.1007/BF00021195

PMID: 7647302

Citation 2: Cammue BP, De Bolle MF, Terras FR, et al. Isolation and characterization of a novel class of plant antimicrobial peptides form Mirabilis jalapa L. seeds. J Biol Chem. 1992;267(4):2228-33. Published 1992 Feb 5. doi:

PMID: 1733929

5.2 Protein Sequence Databases

UniProt: P25403

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P25403

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	U15538	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR013006, IPR009101, IPR024206

PANTHER: Not found

PROSITE: PS60011

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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