AMPDB_7 | Guanylate-binding protein 6

PEPTIDE SUMMARY

Guanylate-binding protein 6

1 General Description

AMPDB ID: AMPDB_7

Protein Names: Guanylate-binding protein 6 (EC 3.6.5.-) (GTP-binding protein 6) (GBP-6) (Guanine nucleotide-binding protein 6) (Macrophage activation 2 like protein)

Protein Family: TRAFAC class dynamin-like GTPase superfamily; GB1 RHD3 GTPase family; GB1 subfamily

Gene Name: Gbp6 Mpa2l

Source Organism: Mus musculus (Mouse)

Protein Length: 611 AA

Protein Existence: Evidence at transcript level

2 Protein Sequence & Composition

2.1 Sequence

MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFIYNSMITINHQALEQLQYVTELTELIRAKSSPNPAGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDDYLENALKLIPGDKPRMQASNSCRECIRLFFPNRKCFVFDRPTHDKELLQKLDSITEDQLDPKFQEVTKAFVSYIFTYAKIKTLKEGIKVTGNRLGILVTTYVNAINSGAVPCLDDAVTTLAQRENSVAVQKAADHYSEQMAQRLRLPTETLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELIGENKELFLSKNEEASNKYCQEELDRLSKDFMENISTFFVPCGHKLYMDKREKIEHDYWQVPRKGVKASEVFQSFLQSQAFIESSILQADTALTAGEKAIAEERAQKVAAEKEQELLRQKQKEQQEYMEAQEKSHKENLEQLRRKLEQEREQDIKDHDMMLKKLMKDQKAFLEEGFKKKAEEMNKEIQQLRDVIKDKKRNTDRIKEALLNGFSTVLFHYLVRYLKHL

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 39, 'R': 24, 'N': 27, 'D': 33, 'C': 10, 'Q': 41, 'E': 60, 'G': 22, 'H': 15, 'I': 31, 'L': 66, 'K': 56, 'M': 18, 'F': 29, 'P': 20, 'S': 33, 'T': 31, 'W': 5, 'Y': 15, 'V': 36

Frequencies of Amino Acids

'A': 6.38%, 'R': 3.93%, 'N': 4.42%, 'D': 5.4%, 'C': 1.64%, 'Q': 6.71%, 'E': 9.82%, 'G': 3.6%, 'H': 2.45%, 'I': 5.07%, 'L': 10.8%, 'K': 9.17%, 'M': 2.95%, 'F': 4.75%, 'P': 3.27%, 'S': 5.4%, 'T': 5.07%, 'W': 0.82%, 'Y': 2.45%, 'V': 5.89%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

266

Hydrophilic Amino Acid(s) Count

345

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	70442.7 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	85.385	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	41.908	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.489	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.703	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	5.927	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-12.166	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.298, 0.167, 0.3 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.08	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	49850, 50475	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Listeria monocytogenes (Gram-positive), Mycobacterium bovis (Gram-positive), Toxoplasma gondii

4.2 Antimicrobial Activity

Antimicrobial, Anti-listeria, Anti-protozoal, Anti-gram-Positive

4.3 Enzymatic Activity

Hydrolase

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Church DM, Goodstadt L, Hillier LW, et al. Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol. 2009;7(5):e1000112. Published 2009 May 5. doi:10.1371/journal.pbio.1000112

PMID: 19468303

Citation 2: Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004;14(10B):2121-7. Published 2004 Oct. doi:10.1101/gr.2596504

PMID: 15489334

Citation 3: Degrandi D, Konermann C, Beuter-Gunia C, et al. Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. J Immunol. 2007;179(11):7729-40. Published 2007 Dec 1. doi:10.4049/jimmunol.179.11.7729

PMID: 18025219

Citation 4: Kim BH, Shenoy AR, Kumar P, et al. A family of IFN-Î³-inducible 65-kD GTPases protects against bacterial infection. Science. 2011;332(6030):717-21. Published 2011 May 6. doi:10.1126/science.1201711

PMID: 21551061

5.2 Protein Sequence Databases

UniProt: A0A0G2JDV3

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A0A0G2JDV3

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AK128993	GenBank \|\| EMBL
2.	GL456119	GenBank \|\| EMBL
3.	BC057969	GenBank \|\| EMBL
4.	BC115768	GenBank \|\| EMBL
5.	BK005759	GenBank \|\| EMBL

CCDS: CCDS19492.1

RefSeq: NP_919317.2, XP_006534750.1

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR030386, IPR037684, IPR003191, IPR036543, IPR015894, IPR027417

PANTHER: Not found

PROSITE: PS51715

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: mmu:100702

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: A0A0G2JDV3

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