AMPDB_688 | Basic phospholipase A2 homolog BmajPLA2-II
PEPTIDE SUMMARY
Basic phospholipase A2 homolog BmajPLA2-II
1 General Description
AMPDB ID: AMPDB_688
Protein Names: Basic phospholipase A2 homolog BmajPLA2-II (svPLA2 homolog)
Protein Family: Phospholipase A2 family; Group II subfamily; K49 sub-subfamily
Gene Name: Nil
Protein Length: 106 AA
Protein Existence: Evidence at protein level
2 Protein Sequence & Composition
2.1 Sequence
NLWQLGKMILLETGKIPAKSYGAYGCNCGVLGRCCYVHKXXXXKLTGCDPKXXXYSYSWKXXTIVCGENNSCLKELCECDKAVAICLRENLDTYNKXXXYNYLKPF
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 4, 'R': 2, 'N': 7, 'D': 3, 'C': 10, 'Q': 1, 'E': 5, 'G': 8, 'H': 1, 'I': 4, 'L': 11, 'K': 11, 'M': 1, 'F': 1, 'P': 3, 'S': 4, 'T': 4, 'W': 2, 'Y': 8, 'V': 4
Frequencies of Amino Acids
'A': 3.77%, 'R': 1.89%, 'N': 6.6%, 'D': 2.83%, 'C': 9.43%, 'Q': 0.94%, 'E': 4.72%, 'G': 7.55%, 'H': 0.94%, 'I': 3.77%, 'L': 10.38%, 'K': 10.38%, 'M': 0.94%, 'F': 0.94%, 'P': 2.83%, 'S': 3.77%, 'T': 3.77%, 'W': 1.89%, 'Y': 7.55%, 'V': 3.77%
Missing Amino Acid(s)
No Amino Acid(s) are missing in this protein
Most Occurring Amino Acid(s)
X
Less Occurring Amino Acid(s)
F, H, M, Q
Hydrophobic Amino Acid(s) Count
38
Hydrophilic Amino Acid(s) Count
56
Basic Amino Acid(s) Count
8
Acidic Amino Acid(s) Count
14
Modified Amino Acid(s) Count
{'X': 12}
Modified Amino Acid(s) Frequencies
{'X': 0.11320754716981132}
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 10661.5 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 69.906 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 27.643 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) -0.225 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.502 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 8.4 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) 4.469 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.283, 0.208, 0.198 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.104 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 22920, 23545 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
C.albicans, E.coli (Gram-negative), Leishmania infantum, Trypanosoma cruzi
4.2 Antimicrobial Activity
Antibiotic, Antimicrobial, Fungicide, Anti-candida, Anti-parasitic, Anti-gram-negative
4.3 Enzymatic Activity
Not found
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Toxin, Non-hemolytic, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: Grabner AN, Alfonso J, Kayano AM, et al. BmajPLA(2)-II, a basic Lys49-phospholipase A(2) homologue from Bothrops marajoensis snake venom with parasiticidal potential. Int J Biol Macromol. 2017;102:571-581. Published 2017 Sep. doi:10.1016/j.ijbiomac.2017.04.013
PMID: 28390830
5.2 Protein Sequence Databases
UniProt: P0DUP9
5.3 3D Structure Databases
No PDB Ids found
AlphaFoldDB: P0DUP9
5.4 Nucleotide Sequence Databases
No entries found in GenBank or EMBL
CCDS: Not found
RefSeq: Not found
5.5 Protein-Protein Interaction Databases
STRING: Not found
IntAct: Not found
MINT: Not found
DIP: Not found
BioGRID: Not found
5.6 Ligand Databases
BindingDB: Not found
DrugBank: Not found
ChEMBL: Not found
5.7 Family & Domain Databases
PANTHER: PTHR11716
PROSITE: Not found
5.8 Genome Annotation Databases
Ensembl: Not found
KEGG: Not found
5.9 Phylogenomic Databases
GeneTree: Not found
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: Not found




© 2023 B&BL, DoAS, IIIT-A, UP-211015, India