AMPDB_681 | M-poneritoxin-Na1b

PEPTIDE SUMMARY

M-poneritoxin-Na1b

1 General Description

AMPDB ID: AMPDB_681

Protein Names: M-poneritoxin-Na1b (M-PONTX-Na1b) (Poneratoxin) (Ponericin Pa II2) (U1-poneritoxin-Na1b) (U1-PONTX-Na1b)

Protein Family: Non-disulfide-bridged peptide (NDBP) superfamily; Medium-length antimicrobial peptide (group 3) family; Ponericin-W subfamily

Gene Name: Nil

Source Organism: Neoponera apicalis (Ant) (Pachycondyla apicalis)

Protein Length: 25 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

FLGALLKIGAKLLPSVVGLFKKKQQ

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 2, 'R': 0, 'N': 0, 'D': 0, 'C': 0, 'Q': 2, 'E': 0, 'G': 3, 'H': 0, 'I': 1, 'L': 6, 'K': 5, 'M': 0, 'F': 2, 'P': 1, 'S': 1, 'T': 0, 'W': 0, 'Y': 0, 'V': 2

Frequencies of Amino Acids

'A': 8%, 'R': 0%, 'N': 0%, 'D': 0%, 'C': 0%, 'Q': 8%, 'E': 0%, 'G': 12%, 'H': 0%, 'I': 4%, 'L': 24%, 'K': 20%, 'M': 0%, 'F': 8%, 'P': 4%, 'S': 4%, 'T': 0%, 'W': 0%, 'Y': 0%, 'V': 8%

Missing Amino Acid(s)

C, D, E, H, M, N, R, T, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

I, P, S

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	2697.39 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	140.4	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	15.796	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.592	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.531	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	11.403	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	4.997	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.44, 0.2, 0.32 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.08	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 0	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

B.malayi, H.contortus, L.cuprina

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytolysis, Toxin, Cytotoxin, Hemolytic, Insecticidal, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Nixon SA, Robinson SD, Agwa AJ, et al. Multipurpose peptides: The venoms of Amazonian stinging ants contain anthelmintic ponericins with diverse predatory and defensive activities. Biochem Pharmacol. 2021;192:114693. Published 2021 Oct. doi:10.1016/j.bcp.2021.114693

PMID: 34302796

Citation 2: Aili SR, Touchard A, Escoubas P, et al. Diversity of peptide toxins from stinging ant venoms. Toxicon. 2014;92:166-78. Published 2014 Dec 15. doi:10.1016/j.toxicon.2014.10.021

PMID: 25448389

Citation 3: Touchard A, Aili SR, Fox EG, et al. The Biochemical Toxin Arsenal from Ant Venoms. Toxins (Basel). 2016;8(1). Published 2016 Jan 20. doi:10.3390/toxins8010030

PMID: 26805882

5.2 Protein Sequence Databases

UniProt: P0DSM4

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P0DSM4

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR012523

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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