AMPDB_633 | Invertebrate-type lysozyme 2
PEPTIDE SUMMARY
Invertebrate-type lysozyme 2
1 General Description
AMPDB ID: AMPDB_633
Protein Names: Invertebrate-type lysozyme 2 (EC 3.2.1.17) (1;4-beta-N-acetylmuramidase)
Protein Family: Glycosyl hydrolase 22 family; Type-I lysozyme subfamily
Gene Name: ilys-2 C45G7.2
Source Organism: Caenorhabditis elegans
Protein Length: 139 AA
Protein Existence: Evidence at transcript level
2 Protein Sequence & Composition
2.1 Sequence
MFVKAILLLSIAVAYASADCLHCICMRESGCKPIGCHMDVGSLSCGYYQIKIPYYEDCGQPGKKHGESTEVAWKRCADDLKCATNCVENYYNRYKHECAGTGQGACEVMARNHNGGPRGCHASGTLGYWKGVHSCCGCS
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 12, 'R': 5, 'N': 5, 'D': 5, 'C': 16, 'Q': 3, 'E': 7, 'G': 17, 'H': 7, 'I': 6, 'L': 7, 'K': 9, 'M': 4, 'F': 1, 'P': 4, 'S': 9, 'T': 4, 'W': 2, 'Y': 9, 'V': 7
Frequencies of Amino Acids
'A': 8.63%, 'R': 3.6%, 'N': 3.6%, 'D': 3.6%, 'C': 11.51%, 'Q': 2.16%, 'E': 5.04%, 'G': 12.23%, 'H': 5.04%, 'I': 4.32%, 'L': 5.04%, 'K': 6.47%, 'M': 2.88%, 'F': 0.72%, 'P': 2.88%, 'S': 6.47%, 'T': 2.88%, 'W': 1.44%, 'Y': 6.47%, 'V': 5.04%
Missing Amino Acid(s)
No Amino Acid(s) are missing in this protein
Most Occurring Amino Acid(s)
G
Less Occurring Amino Acid(s)
F
Hydrophobic Amino Acid(s) Count
60
Hydrophilic Amino Acid(s) Count
79
Basic Amino Acid(s) Count
12
Acidic Amino Acid(s) Count
21
Modified Amino Acid(s) Count
0
Modified Amino Acid(s) Frequencies
0
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 15074.3 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 59.712 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 31.52 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) -0.228 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.579 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 7.713 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) 1.647 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.23, 0.252, 0.216 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.086 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 24410, 25410 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
S.aureus (Gram-positive)
4.2 Antimicrobial Activity
Antibiotic, Antimicrobial, Bacteriolytic enzyme, Anti-gram-Positive
4.3 Enzymatic Activity
Glycosidase, Hydrolase
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Non-hemolytic, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: C. elegans Sequencing Consortium. Genome sequence of the nematode C. elegans: a platform for investigating biology. Science. 1998;282(5396):2012-8. Published 1998 Dec 11. doi:10.1126/science.282.5396.2012
PMID: 9851916
Citation 2: Visvikis O, Ihuegbu N, Labed SA, et al. Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes. Immunity. 2014;40(6):896-909. Published 2014 Jun 19. doi:10.1016/j.immuni.2014.05.002
PMID: 24882217
Citation 3: Gravato-Nobre MJ, Vaz F, Filipe S, et al. The Invertebrate Lysozyme Effector ILYS-3 Is Systemically Activated in Response to Danger Signals and Confers Antimicrobial Protection in C. elegans. PLoS Pathog. 2016;12(8):e1005826. Published 2016 Aug. doi:10.1371/journal.ppat.1005826
PMID: 27525822
5.2 Protein Sequence Databases
UniProt: O76358
5.3 3D Structure Databases
No PDB Ids found
AlphaFoldDB: O76358
5.4 Nucleotide Sequence Databases
Sl. no. Accession(s) Access Link(s)
1. BX284604 GenBank || EMBL
CCDS: Not found
RefSeq: NP_500207.1
5.5 Protein-Protein Interaction Databases
STRING: 6239.C45G7.2
IntAct: Not found
MINT: Not found
DIP: Not found
BioGRID: Not found
5.6 Ligand Databases
BindingDB: Not found
DrugBank: Not found
ChEMBL: Not found
5.7 Family & Domain Databases
InterPro: IPR008597, IPR023346
PANTHER: PTHR11195
PROSITE: PS51909
5.8 Genome Annotation Databases
5.9 Phylogenomic Databases
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: Not found




© 2023 B&BL, DoAS, IIIT-A, UP-211015, India