AMPDB_628 | Lysozyme-like protein 2

PEPTIDE SUMMARY

Lysozyme-like protein 2

1 General Description

AMPDB ID: AMPDB_628

Protein Names: Lysozyme-like protein 2

Protein Family: Glycosyl hydrolase 25 family

Gene Name: lys-2 Y22F5A.5

Source Organism: Caenorhabditis elegans

Protein Length: 279 AA

Protein Existence: Evidence at transcript level

2 Protein Sequence & Composition

2.1 Sequence

MIKLLVSFTILFVLSSARPQEIDSNQAAIANTEANEAPVIVNNDASMGNAVDFSFPTNVQVMNCLKKAKYQVVFLRGFVPTGNGAFDSNCVGNIRNAYSAGLGIETYMTPQPISSWQGYQQLDLLYNGLNNNGITIRSVWIQVTSPANWPNNPTANVNFINSIISRAQQYGLSVGIYTNQYDWSQITGNSANINSNVMLWYWNVLGGGTSGETKPTFADFRAFGPFKKASVKQYAQVETVCNLVVNRDVYAVGIPAAAPKTEVNMADGEKIVVGGFVGN

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 25, 'R': 7, 'N': 32, 'D': 9, 'C': 3, 'Q': 15, 'E': 8, 'G': 23, 'H': 0, 'I': 19, 'L': 15, 'K': 10, 'M': 6, 'F': 13, 'P': 13, 'S': 20, 'T': 16, 'W': 6, 'Y': 11, 'V': 28

Frequencies of Amino Acids

'A': 8.96%, 'R': 2.51%, 'N': 11.47%, 'D': 3.23%, 'C': 1.08%, 'Q': 5.38%, 'E': 2.87%, 'G': 8.24%, 'H': 0%, 'I': 6.81%, 'L': 5.38%, 'K': 3.58%, 'M': 2.15%, 'F': 4.66%, 'P': 4.66%, 'S': 7.17%, 'T': 5.73%, 'W': 2.15%, 'Y': 3.94%, 'V': 10.04%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

148

Hydrophilic Amino Acid(s) Count

131

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	30291.2 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	85.591	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	26.1	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.039	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.59	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	6.567	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-0.182	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.33, 0.315, 0.194 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.108	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	49390, 49515	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

B.thuringiensis (Gram-positive), P.aeruginosa (Gram-negative)

4.2 Antimicrobial Activity

Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: C. elegans Sequencing Consortium. Genome sequence of the nematode C. elegans: a platform for investigating biology. Science. 1998;282(5396):2012-8. Published 1998 Dec 11. doi:10.1126/science.282.5396.2012

PMID: 9851916

Citation 2: Boehnisch C, Wong D, Habig M, et al. Protist-type lysozymes of the nematode Caenorhabditis elegans contribute to resistance against pathogenic Bacillus thuringiensis. PLoS One. 2011;6(9):e24619. Published 2011. doi:10.1371/journal.pone.0024619

PMID: 21931778

Citation 3: Pellegrino MW, Nargund AM, Kirienko NV, et al. Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection. Nature. 2014;516(7531):414-7. Published 2014 Dec 18. doi:10.1038/nature13818

PMID: 25274306

5.2 Protein Sequence Databases

UniProt: O62416

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: O62416

5.4 Nucleotide Sequence Databases