AMPDB_6170 | HNHc domain-containing protein

PEPTIDE SUMMARY

HNHc domain-containing protein

1 General Description

AMPDB ID: AMPDB_6170

Protein Names: HNHc domain-containing protein

Protein Family: Colicin pyosin nuclease family

Gene Name: AB204_10650

Source Organism: Xenorhabdus khoisanae

Protein Length: 626 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MSGGDGMGHNSGAHNSGGGINGGPTGFGGGGGNSGNSYSDNSGWSSENNPWGGGSSGGSSGPDGSNSGNSGDSNSGRRGDKNAKAKAIGELTTISAVAGTLTIATYNPFSSPFGSITLSELAAFFAETLTKAAPIAGRLLGVFGLFYPSSIGTEPPIDLNLRNREDNSYNVITLPTLMVSGVPAEDIPENTSVPANVLAQPVFDEVTKTRRVAITPVQATPVPVVKAEKTDEPNVYTAQVVPGMKPMRINVMNSKPGKQNQAKVNTTPALGQYLPAATEKDTHHAILDFGGEHDSIYISVSRTPKLDEEKKQLEEARRDWEERYPVEAAQEKLDIVNNELYKTRAEVNINQGLLNNLKNTPEGLALSNPRQHPIKSESYYEESVTSGPYRGTVSGTATAIIDSQENLNYLLAHDGLAYKRNILNDKDVVLSDDVEGDTIIYEAEYGEYDKLRQRLLDTRNRIAEAEKNLALAKKSEKEAENKKKTAQDKVDKENKRNQPGTATGKGKPVGDKWLHDAGKENGAPIPDRIADKLRGKKFRNFDDFRKQFWEEVSKDPELSKQFNKSNRKHITEGRSPYVPENEQVGGREVNEIHHNKPISQGGEVYDMDNLRITTPKRHIEIHRGKK

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 45, 'R': 31, 'N': 49, 'D': 36, 'C': 0, 'Q': 18, 'E': 49, 'G': 63, 'H': 13, 'I': 32, 'L': 40, 'K': 48, 'M': 7, 'F': 14, 'P': 38, 'S': 46, 'T': 38, 'W': 5, 'Y': 19, 'V': 35

Frequencies of Amino Acids

'A': 7.19%, 'R': 4.95%, 'N': 7.83%, 'D': 5.75%, 'C': 0%, 'Q': 2.88%, 'E': 7.83%, 'G': 10.06%, 'H': 2.08%, 'I': 5.11%, 'L': 6.39%, 'K': 7.67%, 'M': 1.12%, 'F': 2.24%, 'P': 6.07%, 'S': 7.35%, 'T': 6.07%, 'W': 0.8%, 'Y': 3.04%, 'V': 5.59%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

279

Hydrophilic Amino Acid(s) Count

347

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	68120.5 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	68.259	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	41.821	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.803	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.661	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	6.595	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-4.748	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.232, 0.313, 0.225 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.061	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	55810, 55810	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Hydrolase

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

No PMID found

5.2 Protein Sequence Databases

UniProt: A0A0J5FS99

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A0A0J5FS99

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	LFCV01000064	GenBank \|\| EMBL

CCDS: Not found

RefSeq: WP_047963343.1

5.5 Protein-Protein Interaction Databases

STRING: 880157.AB204_10650

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR014740, IPR038452, IPR014739, IPR037146, IPR044925, IPR003615, IPR016128, IPR036302

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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