AMPDB_611 | Fungal defensin micasin

PEPTIDE SUMMARY

Fungal defensin micasin

1 General Description

AMPDB ID: AMPDB_611

Protein Names: Fungal defensin micasin (Fungal defensin-like peptide) (DLP) (fDLP)

Protein Family: Invertebrate defensin family

Gene Name: Nil

Source Organism: Arthroderma otae (Microsporum canis)

Protein Length: 81 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MQFTKLATILLVSLMGSAAIAAPATNNAAVDAAADATPAVEKRGFGCPFNENECHAHCLSIGRKFGFCAGPLRATCTCGKQ

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 16, 'R': 3, 'N': 4, 'D': 2, 'C': 6, 'Q': 2, 'E': 3, 'G': 7, 'H': 2, 'I': 3, 'L': 6, 'K': 4, 'M': 2, 'F': 5, 'P': 4, 'S': 3, 'T': 6, 'W': 0, 'Y': 0, 'V': 3

Frequencies of Amino Acids

'A': 19.75%, 'R': 3.7%, 'N': 4.94%, 'D': 2.47%, 'C': 7.41%, 'Q': 2.47%, 'E': 3.7%, 'G': 8.64%, 'H': 2.47%, 'I': 3.7%, 'L': 7.41%, 'K': 4.94%, 'M': 2.47%, 'F': 6.17%, 'P': 4.94%, 'S': 3.7%, 'T': 7.41%, 'W': 0%, 'Y': 0%, 'V': 3.7%

Missing Amino Acid(s)

W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

D, H, M, Q

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	8329.65 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	73.827	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	38.507	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.256	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.45	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	8.127	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	1.813	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.21, 0.222, 0.333 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.062	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 375	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

P.aeruginosa (Gram-negative), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Defensin, Anti-yeast, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytotoxin, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Zhu S, Gao B, Harvey PJ, et al. Dermatophytic defensin with antiinfective potential. Proc Natl Acad Sci U S A. 2012;109(22):8495-500. Published 2012 May 29. doi:10.1073/pnas.1201263109

PMID: 22586077

Citation 2: Wu J, Gao B, Zhu S, et al. Single-point mutation-mediated local amphipathic adjustment dramatically enhances antibacterial activity of a fungal defensin. FASEB J. 2016;30(7):2602-14. Published 2016 Jul. doi:10.1096/fj.201500157

PMID: 27084888

5.2 Protein Sequence Databases

UniProt: I1T3C7

5.3 3D Structure Databases

	Sl. no.	PDB ID	Method	Resolution	Access Links	3D View

AlphaFoldDB: I1T3C7

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	JN014007	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR001542, IPR036574

PANTHER: Not found

PROSITE: PS51378

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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