AMPDB_607 | Lantibiotic macedovicin

PEPTIDE SUMMARY

Lantibiotic macedovicin

1 General Description

AMPDB ID: AMPDB_607

Protein Names: Lantibiotic macedovicin

Protein Family: Type A lantibiotic family

Gene Name: SMA_1409

Source Organism: Streptococcus macedonicus (strain ACA-DC 198)

Protein Length: 58 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MMNATENQIFVETVSDQELEMLIGGADRGWIKTLTKDCPNVISSICAGTIITACKNCA

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 5, 'R': 1, 'N': 4, 'D': 3, 'C': 4, 'Q': 2, 'E': 4, 'G': 4, 'H': 0, 'I': 7, 'L': 3, 'K': 3, 'M': 3, 'F': 1, 'P': 1, 'S': 3, 'T': 6, 'W': 1, 'Y': 0, 'V': 3

Frequencies of Amino Acids

'A': 8.62%, 'R': 1.72%, 'N': 6.9%, 'D': 5.17%, 'C': 6.9%, 'Q': 3.45%, 'E': 6.9%, 'G': 6.9%, 'H': 0%, 'I': 12.07%, 'L': 5.17%, 'K': 5.17%, 'M': 5.17%, 'F': 1.72%, 'P': 1.72%, 'S': 5.17%, 'T': 10.34%, 'W': 1.72%, 'Y': 0%, 'V': 5.17%

Missing Amino Acid(s)

H, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

F, P, R, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	6250.23 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	90.862	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	24.029	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.183	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.565	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	4.194	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-3.242	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.259, 0.207, 0.259 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.034	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	5500, 5750	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Clostridium spp. (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Lantibiotic, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Papadimitriou K, Ferreira S, Papandreou NC, et al. Complete genome sequence of the dairy isolate Streptococcus macedonicus ACA-DC 198. J Bacteriol. 2012;194(7):1838-9. Published 2012 Apr. doi:10.1128/JB.06804-11

PMID: 22408241

Citation 2: Georgalaki M, Papadimitriou K, Anastasiou R, et al. Macedovicin, the second food-grade lantibiotic produced by Streptococcus macedonicus ACA-DC 198. Food Microbiol. 2013;33(1):124-30. Published 2013 Feb. doi:10.1016/j.fm.2012.09.008

PMID: 23122510

5.2 Protein Sequence Databases

UniProt: H2A7G5

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: H2A7G5

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	HE613569	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: 1116231.SMA_1409

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR007682

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: smn:SMA_1409

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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