AMPDB_605 | Antimicrobial peptide 1
PEPTIDE SUMMARY
Antimicrobial peptide 1
1 General Description
AMPDB ID: AMPDB_605
Protein Names: Antimicrobial peptide 1 (AamAP1) (Non-disulfide-bridged peptide 4.11) (NDBP-4.11)
Protein Family: Non-disulfide-bridged peptide (NDBP) superfamily; Short antimicrobial peptide (group 4) family
Gene Name: Nil
Protein Length: 74 AA
Protein Existence: Evidence at protein level
2 Protein Sequence & Composition
2.1 Sequence
MEIKYLLTVFLVLLIGSDYCQAFLFSLIPHAIGGLISAFKGRRKRDLDGQIDRSRNFRKRDAELEELLSKLPIY
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 4, 'R': 7, 'N': 1, 'D': 5, 'C': 1, 'Q': 2, 'E': 4, 'G': 5, 'H': 1, 'I': 7, 'L': 13, 'K': 5, 'M': 1, 'F': 5, 'P': 2, 'S': 5, 'T': 1, 'W': 0, 'Y': 3, 'V': 2
Frequencies of Amino Acids
'A': 5.41%, 'R': 9.46%, 'N': 1.35%, 'D': 6.76%, 'C': 1.35%, 'Q': 2.7%, 'E': 5.41%, 'G': 6.76%, 'H': 1.35%, 'I': 9.46%, 'L': 17.57%, 'K': 6.76%, 'M': 1.35%, 'F': 6.76%, 'P': 2.7%, 'S': 6.76%, 'T': 1.35%, 'W': 0%, 'Y': 4.05%, 'V': 2.7%
Missing Amino Acid(s)
W
Most Occurring Amino Acid(s)
L
Less Occurring Amino Acid(s)
C, H, M, N, T
Hydrophobic Amino Acid(s) Count
39
Hydrophilic Amino Acid(s) Count
35
Basic Amino Acid(s) Count
9
Acidic Amino Acid(s) Count
13
Modified Amino Acid(s) Count
0
Modified Amino Acid(s) Frequencies
0
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 8573.11 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 118.649 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 37.972 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) 0.066 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.48 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 9.659 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) 3.032 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.405, 0.176, 0.297 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.108 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 4470, 4470 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
C.albicans, E.coli (Gram-negative), S.aureus (Gram-positive)
4.2 Antimicrobial Activity
Antibiotic, Antimicrobial, Anti-candida, Anti-gram-negative, Anti-gram-Positive
4.3 Enzymatic Activity
Not found
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Cytolysis, Hemolytic, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: Almaaytah A, Zhou M, Wang L, et al. Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. Peptides. 2012;35(2):291-9. Published 2012 Jun. doi:10.1016/j.peptides.2012.03.016
PMID: 22484288
Citation 2: Almaaytah A, Albalas Q, Albalas Q. Scorpion venom peptides with no disulfide bridges: a review. Peptides. 2014;51:35-45. Published 2014 Jan. doi:10.1016/j.peptides.2013.10.021
PMID: 24184590
5.2 Protein Sequence Databases
UniProt: G8YYA5
5.3 3D Structure Databases
No PDB Ids found
AlphaFoldDB: G8YYA5
5.4 Nucleotide Sequence Databases
Sl. no. Accession(s) Access Link(s)
1. FR821613 GenBank || EMBL
CCDS: Not found
RefSeq: Not found
5.5 Protein-Protein Interaction Databases
STRING: Not found
IntAct: Not found
MINT: Not found
DIP: Not found
BioGRID: Not found
5.6 Ligand Databases
BindingDB: Not found
DrugBank: Not found
ChEMBL: Not found
5.7 Family & Domain Databases
InterPro: Not found
PANTHER: Not found
PROSITE: Not found
5.8 Genome Annotation Databases
Ensembl: Not found
KEGG: Not found
5.9 Phylogenomic Databases
GeneTree: Not found
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: Not found




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