AMPDB_593 | Cliotide T4

PEPTIDE SUMMARY

Cliotide T4

1 General Description

AMPDB ID: AMPDB_593

Protein Names: Cliotide T4

Protein Family: Cyclotide family; Bracelet subfamily

Gene Name: Nil

Source Organism: Clitoria ternatea (Butterfly pea)

Protein Length: 123 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MASLRIAPLALFFFLAASVMFTVEKTEAGIPCGESCVFIPCITAAIGCSCKSKVCYRNHVIAAEAKTMDDHHLLCQSHEDCITKGTGNFCAPFPDQDIKYGWCFRAESEGFLLKDHLKMSITN

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 13, 'R': 3, 'N': 3, 'D': 6, 'C': 10, 'Q': 2, 'E': 7, 'G': 7, 'H': 5, 'I': 9, 'L': 9, 'K': 8, 'M': 4, 'F': 9, 'P': 5, 'S': 8, 'T': 7, 'W': 1, 'Y': 2, 'V': 5

Frequencies of Amino Acids

'A': 10.57%, 'R': 2.44%, 'N': 2.44%, 'D': 4.88%, 'C': 8.13%, 'Q': 1.63%, 'E': 5.69%, 'G': 5.69%, 'H': 4.07%, 'I': 7.32%, 'L': 7.32%, 'K': 6.5%, 'M': 3.25%, 'F': 7.32%, 'P': 4.07%, 'S': 6.5%, 'T': 5.69%, 'W': 0.81%, 'Y': 1.63%, 'V': 4.07%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	13529.8 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	79.431	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	30.381	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.224	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.454	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	6.635	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-2.156	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.285, 0.187, 0.268 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.098	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	8480, 9105	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative), K.pneumoniae (Gram-negative), P.aeruginosa (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Plant defense, Anti-gram-negative

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytolysis, Cytotoxin, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Nguyen GK, Zhang S, Nguyen NT, et al. Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family. J Biol Chem. 2011;286(27):24275-87. Published 2011 Jul 8. doi:10.1074/jbc.M111.229922

PMID: 21596752

5.2 Protein Sequence Databases

UniProt: G1CWH3

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: G1CWH3

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	JF931991	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR032000, IPR005535, IPR012323, IPR036146

PANTHER: Not found

PROSITE: PS51052, PS60008

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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