AMPDB_593 | Cliotide T4
PEPTIDE SUMMARY
Cliotide T4
1 General Description
AMPDB ID: AMPDB_593
Protein Names: Cliotide T4
Protein Family: Cyclotide family; Bracelet subfamily
Gene Name: Nil
Protein Length: 123 AA
Protein Existence: Evidence at protein level
2 Protein Sequence & Composition
2.1 Sequence
MASLRIAPLALFFFLAASVMFTVEKTEAGIPCGESCVFIPCITAAIGCSCKSKVCYRNHVIAAEAKTMDDHHLLCQSHEDCITKGTGNFCAPFPDQDIKYGWCFRAESEGFLLKDHLKMSITN
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 13, 'R': 3, 'N': 3, 'D': 6, 'C': 10, 'Q': 2, 'E': 7, 'G': 7, 'H': 5, 'I': 9, 'L': 9, 'K': 8, 'M': 4, 'F': 9, 'P': 5, 'S': 8, 'T': 7, 'W': 1, 'Y': 2, 'V': 5
Frequencies of Amino Acids
'A': 10.57%, 'R': 2.44%, 'N': 2.44%, 'D': 4.88%, 'C': 8.13%, 'Q': 1.63%, 'E': 5.69%, 'G': 5.69%, 'H': 4.07%, 'I': 7.32%, 'L': 7.32%, 'K': 6.5%, 'M': 3.25%, 'F': 7.32%, 'P': 4.07%, 'S': 6.5%, 'T': 5.69%, 'W': 0.81%, 'Y': 1.63%, 'V': 4.07%
Missing Amino Acid(s)
No Amino Acid(s) are missing in this protein
Most Occurring Amino Acid(s)
A
Less Occurring Amino Acid(s)
W
Hydrophobic Amino Acid(s) Count
62
Hydrophilic Amino Acid(s) Count
61
Basic Amino Acid(s) Count
13
Acidic Amino Acid(s) Count
16
Modified Amino Acid(s) Count
0
Modified Amino Acid(s) Frequencies
0
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 13529.8 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 79.431 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 30.381 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) 0.224 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.454 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 6.635 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) -2.156 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.285, 0.187, 0.268 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.098 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 8480, 9105 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
E.coli (Gram-negative), K.pneumoniae (Gram-negative), P.aeruginosa (Gram-negative)
4.2 Antimicrobial Activity
Antibiotic, Antimicrobial, Plant defense, Anti-gram-negative
4.3 Enzymatic Activity
Not found
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Cytolysis, Cytotoxin, Hemolytic, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: Nguyen GK, Zhang S, Nguyen NT, et al. Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family. J Biol Chem. 2011;286(27):24275-87. Published 2011 Jul 8. doi:10.1074/jbc.M111.229922
PMID: 21596752
5.2 Protein Sequence Databases
UniProt: G1CWH3
5.3 3D Structure Databases
No PDB Ids found
AlphaFoldDB: G1CWH3
5.4 Nucleotide Sequence Databases
Sl. no. Accession(s) Access Link(s)
1. JF931991 GenBank || EMBL
CCDS: Not found
RefSeq: Not found
5.5 Protein-Protein Interaction Databases
STRING: Not found
IntAct: Not found
MINT: Not found
DIP: Not found
BioGRID: Not found
5.6 Ligand Databases
BindingDB: Not found
DrugBank: Not found
ChEMBL: Not found
5.7 Family & Domain Databases
PANTHER: Not found
PROSITE: PS51052, PS60008
5.8 Genome Annotation Databases
Ensembl: Not found
KEGG: Not found
5.9 Phylogenomic Databases
GeneTree: Not found
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: Not found




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