AMPDB_5831 | Pyocin S1

PEPTIDE SUMMARY

Pyocin S1

1 General Description

AMPDB ID: AMPDB_5831

Protein Names: Pyocin S1

Protein Family: Colicin pyosin nuclease family

Gene Name: KPNJ1_05657

Source Organism: Klebsiella pneumoniae 30660 NJST258_1

Protein Length: 784 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MENKKNKRRKCVIGGFNYNGEGATSSGLSSPSASDVANQFNSFGGTQIRASDVSNIRSDGNGGYMADIRGQIHTVSSEEGSTTVSGFDGVRSSSTGNGGSQGGQGPQGQSLVMHNGQMGYWENRSSGAGNNEHTTRAFVAVGPSEAEKAARAEKVAKEKQQAEEAAKAFAAKTAAASAAAEKERQNAISAAAAAGQHQTVPDARNNLNQATAEASRLKTVADNALNTAKNKRKEAIDAVPVATQAEKKYQDLQQSIKGLTLNNNGQYGTQKWEVISSNKEHDHWGYRFYPSGITKAQVDAAQNDAVNKRNAATSLASQATAAEQASLQASAAYNAAETRRQAAQAALASAEQAAAAERKRQEAEAAAAAAAEKKRQADAAAKAAEEARAIAEKAKALQARCTAADKLKSSEIQAVRGIPATAAPFAIPLTWSTASRGGFTLSADAAASLGAFISEALATLSVAVVANPVALTIAGLVLSKSVGVGSDMVPGRDISSMMPGDAFGLPDTAALNKAADQKTSVSMPVRGRLVMNDSGILDVQLVKTNTAGAVKVARAVLDKETGYWGYTLPAVADVPAQTIFVSPADALGANGPLTLSGPVPLPERILHTGDQISAPQATDKTVTPVADDLDFDDIILVFPPESGLKPLYVMYRSPRNMPGTVSGKGQNVGNNWMGGASTGDGAPVPSQIADKLRGKTFGSFDSSRRAFWKAVADDSALSKQFSEADINQMKAGRAPTADFLESVGKRVKIELHHEKEISQGGAVMDVDNIKALTPKNHIETHKGK

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 138, 'R': 36, 'N': 40, 'D': 41, 'C': 2, 'Q': 42, 'E': 40, 'G': 67, 'H': 11, 'I': 29, 'L': 42, 'K': 51, 'M': 14, 'F': 19, 'P': 32, 'S': 66, 'T': 45, 'W': 7, 'Y': 12, 'V': 50

Frequencies of Amino Acids

'A': 17.6%, 'R': 4.59%, 'N': 5.1%, 'D': 5.23%, 'C': 0.26%, 'Q': 5.36%, 'E': 5.1%, 'G': 8.55%, 'H': 1.4%, 'I': 3.7%, 'L': 5.36%, 'K': 6.51%, 'M': 1.79%, 'F': 2.42%, 'P': 4.08%, 'S': 8.42%, 'T': 5.74%, 'W': 0.89%, 'Y': 1.53%, 'V': 6.38%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

398

Hydrophilic Amino Acid(s) Count

386

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	81642.9 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	71.416	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	40.208	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.405	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.632	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.329	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	6.938	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.203, 0.261, 0.298 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.048	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	56380, 56505	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Hydrolase

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Deleo FR, Chen L, Porcella SF, et al. Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae. Proc Natl Acad Sci U S A. 2014;111(13):4988-93. Published 2014 Apr 1. doi:10.1073/pnas.1321364111

PMID: 24639510

5.2 Protein Sequence Databases

UniProt: A0A0E1CMU1

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A0A0E1CMU1

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	CP006927	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR037146, IPR044925, IPR003615, IPR016128, IPR036302

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: kpa:KPNJ1_05657

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

Download