AMPDB_58114 | Klebicin C activity

PEPTIDE SUMMARY

Klebicin C activity

1 General Description

AMPDB ID: AMPDB_58114

Protein Names: Klebicin C activity

Protein Family: Nil

Gene Name: kca

Source Organism: Klebsiella oxytoca

Protein Length: 619 AA

Protein Existence: Predicted

2 Protein Sequence & Composition

2.1 Sequence

MADNQPVPLTPAPPGMVSLGVNENGEEEMTVIGGDGSGTGFSGNEAPIIPGSGSLQADLGKKSLTRLQAESSAAIHATAKWTTENLAKTQAAQAERAKAAMLSQQAAKAKQAKLTQHLKDVVDRALQNNKTRPTVIDLAHQNNQQMAAMAEFIGRQKAIEEARKKAEREAKRAEEAYQAALRAQEEEQRKQAEIERKLQEARKQEAAAKAKAEADRIAAEKAEAEARAKAEAERRKAEEARKALFAKAGIKDTPVYTLEMTKAATTLFLTPGVRLLNRAPAMIQLSALAAEINGVLTTAASAVMTATAEFSGWIASALWRGVAGVATASTVGPMVAAASTLFFSPRAGGGSDSKVPGRDIEMLAAQARLFTAGKLSIEPGMKSVNLPVRGFISSETDGRQSLMLVKTGSDGVPSTVPVLDAVRDSTTGLDKITVPAMSGAPSRTILVNPVPIGPAAPWHTGNSGPVPVTPVHTGTEVKQADSIVTTTLPIADIPPLQDFIYWQPDASGTGVEPIYVMTSQPRKGVKDYGHDYHPAPKTEEIKGLGELIESRKKTPKQGGGGRRDRWVGDKGRKIYEWDSQHGELEGYRASDGSHLGAFDPNTGKQLKGPDPKRNIKKYL

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 91, 'R': 35, 'N': 16, 'D': 27, 'C': 0, 'Q': 30, 'E': 45, 'G': 54, 'H': 9, 'I': 28, 'L': 42, 'K': 46, 'M': 15, 'F': 11, 'P': 39, 'S': 36, 'T': 44, 'W': 7, 'Y': 9, 'V': 35

Frequencies of Amino Acids

'A': 14.7%, 'R': 5.65%, 'N': 2.58%, 'D': 4.36%, 'C': 0%, 'Q': 4.85%, 'E': 7.27%, 'G': 8.72%, 'H': 1.45%, 'I': 4.52%, 'L': 6.79%, 'K': 7.43%, 'M': 2.42%, 'F': 1.78%, 'P': 6.3%, 'S': 5.82%, 'T': 7.11%, 'W': 1.13%, 'Y': 1.45%, 'V': 5.65%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

322

Hydrophilic Amino Acid(s) Count

297

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	65871.7 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	75.202	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	42.423	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.46	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.74	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.857	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	9.887	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.213, 0.234, 0.312 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.044	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	51910, 51910	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Chavan M, Rafi H, Wertz J, et al. Phage associated bacteriocins reveal a novel mechanism for bacteriocin diversification in Klebsiella. J Mol Evol. 2005;60(4):546-56. Published 2005 Apr. doi:10.1007/s00239-004-0263-9

PMID: 15883889

5.2 Protein Sequence Databases

UniProt: Q5V9J6

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: Q5V9J6

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AY578794	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR036725, IPR009105, IPR016128, IPR036302

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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