AMPDB_57945 | Uropathogenic specific protein

PEPTIDE SUMMARY

Uropathogenic specific protein

1 General Description

AMPDB ID: AMPDB_57945

Protein Names: Uropathogenic specific protein (EC 3.1.21.1)

Protein Family: Colicin pyosin nuclease family

Gene Name: usp UTI89_C0121

Source Organism: Escherichia coli (strain UTI89 UPEC)

Protein Length: 593 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MGDIVYLRIIGEKQGDISSGCGTYASVGNRWQVGHEDEIFAFALTNAITSTGKGVNLQGLQFCKLIDKSSPLLSNAINQNERLFIEIDLYRINKSGRWERYYYIQLRNASLTAIHVNISDNNLPTECVNVNYDYILCKHLIANTEFDWLAFPAGYNSLFIPPKNPPASNLNPEPLPVVNLPLSPPAVKPVYAKSCLKEKGCTDAGTAEEPAENFGQVAIFALPVVDDCCGYHHPEANDVGQPAEAQTMLLFPGSVLAAQIWGKWSLSGILSATCGSYIGALASALYIPSAGEGSARVPGRDEFWYEEELRQKALAGSTATTRVRFFWGTDIHGKPQVYGVHTGEGTPYENVRVANMQWNEQTQRYEFTPAHDVDGPLITWTPENPEHGYVPGHTGNDRPPLEQPTILVTPIPDGTDTYTTPPFPVPDPKEFNDYILVFPAGSGIKPIYVYLKEDPRKLPGVVTGRGVPLSPGTRWLDMSVSNNGNGAPIPAHIADKLRGREFKTFDEFREALWLEVSQDPELIAQFSSGNQTRIKQGLTAKAPIDGWYYGPKEIVKKFQIHHRVAVEYGGSVYDIDNLRIVTPRLHDEIHYRR

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 43, 'R': 27, 'N': 32, 'D': 30, 'C': 9, 'Q': 21, 'E': 37, 'G': 51, 'H': 15, 'I': 39, 'L': 46, 'K': 25, 'M': 4, 'F': 22, 'P': 50, 'S': 31, 'T': 34, 'W': 12, 'Y': 27, 'V': 38

Frequencies of Amino Acids

'A': 7.25%, 'R': 4.55%, 'N': 5.4%, 'D': 5.06%, 'C': 1.52%, 'Q': 3.54%, 'E': 6.24%, 'G': 8.6%, 'H': 2.53%, 'I': 6.58%, 'L': 7.76%, 'K': 4.22%, 'M': 0.67%, 'F': 3.71%, 'P': 8.43%, 'S': 5.23%, 'T': 5.73%, 'W': 2.02%, 'Y': 4.55%, 'V': 6.41%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

305

Hydrophilic Amino Acid(s) Count

288

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	65744.2 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	81.737	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	37.861	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.342	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.558	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	5.606	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-14.148	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.31, 0.277, 0.219 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.103	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	106230, 106730	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Hydrolase

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Chen SL, Hung CS, Xu J, et al. Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach. Proc Natl Acad Sci U S A. 2006;103(15):5977-82. Published 2006 Apr 11. doi:10.1073/pnas.0600938103

PMID: 16585510

5.2 Protein Sequence Databases

UniProt: Q1RG83

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: Q1RG83

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	CP000243	GenBank \|\| EMBL

CCDS: Not found

RefSeq: WP_000502504.1

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR037146, IPR036624, IPR044925, IPR003615, IPR016128, IPR036302, IPR008514

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: eci:UTI89_C0121

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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