AMPDB_53 | Cypemycin

PEPTIDE SUMMARY

Cypemycin

1 General Description

AMPDB ID: AMPDB_53

Protein Names: Cypemycin

Protein Family: Linaridin family

Gene Name: cypA

Source Organism: Streptomyces sp

Protein Length: 64 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MRSEMTLTSTNSAEALAAQDFANTVLSAAAPGFHADCETPAMATPATPTVAQFVIQGSTICLVC

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 13, 'R': 1, 'N': 2, 'D': 2, 'C': 3, 'Q': 3, 'E': 3, 'G': 2, 'H': 1, 'I': 2, 'L': 4, 'K': 0, 'M': 3, 'F': 3, 'P': 4, 'S': 5, 'T': 9, 'W': 0, 'Y': 0, 'V': 4

Frequencies of Amino Acids

'A': 20.31%, 'R': 1.56%, 'N': 3.13%, 'D': 3.13%, 'C': 4.69%, 'Q': 4.69%, 'E': 4.69%, 'G': 3.13%, 'H': 1.56%, 'I': 3.13%, 'L': 6.25%, 'K': 0%, 'M': 4.69%, 'F': 4.69%, 'P': 6.25%, 'S': 7.81%, 'T': 14.06%, 'W': 0%, 'Y': 0%, 'V': 6.25%

Missing Amino Acid(s)

K, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

H, R

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	6533.41 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	75	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	27.708	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.403	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.458	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	3.951	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-4.091	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.203, 0.203, 0.359 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.047	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 125	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

M.luteus (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytotoxin, Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Claesen J, Bibb M, Bibb M. Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of posttranslationally modified peptides. Proc Natl Acad Sci U S A. 2010;107(37):16297-302. Published 2010 Sep 14. doi:10.1073/pnas.1008608107

PMID: 20805503

Citation 2: Komiyama K, Otoguro K, Segawa T, et al. A new antibiotic, cypemycin. Taxonomy, fermentation, isolation and biological characteristics. J Antibiot (Tokyo). 1993;46(11):1666-71. Published 1993 Nov. doi:10.7164/antibiotics.46.1666

PMID: 7802859

5.2 Protein Sequence Databases

UniProt: E5KIB6

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: E5KIB6

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	HQ148718	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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