AMPDB_527 | Antimicrobial peptide Xac-1

PEPTIDE SUMMARY

Antimicrobial peptide Xac-1

1 General Description

AMPDB ID: AMPDB_527

Protein Names: Antimicrobial peptide Xac-1 (Xylopin)

Protein Family: Nil

Gene Name: Nil

Source Organism: Xylocopa appendiculata circumvolans (Japanese carpenter bee)

Protein Length: 17 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

GFVALLKKLPLILKHLH

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 1, 'R': 0, 'N': 0, 'D': 0, 'C': 0, 'Q': 0, 'E': 0, 'G': 1, 'H': 2, 'I': 1, 'L': 6, 'K': 3, 'M': 0, 'F': 1, 'P': 1, 'S': 0, 'T': 0, 'W': 0, 'Y': 0, 'V': 1

Frequencies of Amino Acids

'A': 5.88%, 'R': 0%, 'N': 0%, 'D': 0%, 'C': 0%, 'Q': 0%, 'E': 0%, 'G': 5.88%, 'H': 11.76%, 'I': 5.88%, 'L': 35.29%, 'K': 17.65%, 'M': 0%, 'F': 5.88%, 'P': 5.88%, 'S': 0%, 'T': 0%, 'W': 0%, 'Y': 0%, 'V': 5.88%

Missing Amino Acid(s)

C, D, E, M, N, Q, R, S, T, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

A, F, G, I, P, V

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	1940.49 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	183.529	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	17.088	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.941	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.554	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	11.103	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	3.179	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.529, 0.118, 0.412 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.059	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 0	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria and Gram Positive Bacteria

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Fungicide, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytolysis, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Kawakami H, Goto SG, Murata K, et al. Isolation of biologically active peptides from the venom of Japanese carpenter bee, Xylocopa appendiculata. J Venom Anim Toxins Incl Trop Dis. 2017;23:29. Published 2017. doi:10.1186/s40409-017-0119-6

PMID: 28546807

Citation 2: Kazuma K, Ando K, Nihei KI, et al. Peptidomic analysis of the venom of the solitary bee Xylocopa appendiculata circumvolans. J Venom Anim Toxins Incl Trop Dis. 2017;23:40. Published 2017. doi:10.1186/s40409-017-0130-y

PMID: 28855917

5.2 Protein Sequence Databases

UniProt: C0HKQ5

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: C0HKQ5

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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