AMPDB_521 | Lasioglossin-2

PEPTIDE SUMMARY

Lasioglossin-2

1 General Description

AMPDB ID: AMPDB_521

Protein Names: Lasioglossin-2 (LL-II)

Protein Family: Nil

Gene Name: Nil

Source Organism: Lasioglossum laticeps (Bee)

Protein Length: 15 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

VNWKKILGKIIKVAK

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 1, 'R': 0, 'N': 1, 'D': 0, 'C': 0, 'Q': 0, 'E': 0, 'G': 1, 'H': 0, 'I': 3, 'L': 1, 'K': 5, 'M': 0, 'F': 0, 'P': 0, 'S': 0, 'T': 0, 'W': 1, 'Y': 0, 'V': 2

Frequencies of Amino Acids

'A': 6.67%, 'R': 0%, 'N': 6.67%, 'D': 0%, 'C': 0%, 'Q': 0%, 'E': 0%, 'G': 6.67%, 'H': 0%, 'I': 20%, 'L': 6.67%, 'K': 33.33%, 'M': 0%, 'F': 0%, 'P': 0%, 'S': 0%, 'T': 0%, 'W': 6.67%, 'Y': 0%, 'V': 13.33%

Missing Amino Acid(s)

C, D, E, F, H, M, P, Q, R, S, T, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

A, G, L, N, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	1738.24 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	149.333	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	-13.04	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.213	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.714	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	11.403	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	4.997	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.467, 0.133, 0.133 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.067	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	5500, 5500	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

B.subtilis (Gram-positive), E.coli (Gram-negative), P.aeruginosa (Gram-negative), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytotoxin, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: CerovskÃ½ V, BudesÃnskÃ½ M, Hovorka O, et al. Lasioglossins: three novel antimicrobial peptides from the venom of the eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae). Chembiochem. 2009;10(12):2089-99. Published 2009 Aug 17. doi:10.1002/cbic.200900133

PMID: 19591185

Citation 2: Bandyopadhyay S, Lee M, Sivaraman J, et al. Model membrane interaction and DNA-binding of antimicrobial peptide Lasioglossin II derived from bee venom. Biochem Biophys Res Commun. 2013;430(1):1-6. Published 2013 Jan 4. doi:10.1016/j.bbrc.2012.11.015

PMID: 23159628

5.2 Protein Sequence Databases

UniProt: C0HK43

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: C0HK43

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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