AMPDB_5184 | Colicin-B

PEPTIDE SUMMARY

Colicin-B

1 General Description

AMPDB ID: AMPDB_5184

Protein Names: Colicin-B (Pore-forming bacteriocin colicin B)

Protein Family: Channel forming colicin family

Gene Name: cba BMT50_29120 C9160_28195 EHD79_20925 GF199_23715 XU56_005235

Source Organism: Escherichia coli

Protein Length: 511 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MSDNEGSVPTEGIDYGDTMVVWPSTGRIPGGDVKPGGSSGLAPSMPPGWGDYSPQGIALVQSVLFPGIIRRIILDKELEEGDWSGWSVSVHSPWGNEKVSAARTVLENGLRGGLPEPSRPAAVSFARLEPASGNEQKIIRLMVTQQLEQVTDIPASQLPAAGNNVPVKYRLTDLMQNGTQYMAIIGGIPMTVPVVDAVPVPDRSRPGTNIKDVYSAPVSPNLPDLVLSVGQMNTPVRSNPEIQEDGVISETGNYVEAGYTMSSNNHDVIVRFPEGSGVSPLYISAVEILDSNSLSQRQEAENNAKDDFRVKKEQENDEKTVLTKTSEVIISVGDKVGEYLGDKYKALSREIAENINNFQGKTIRSYDDAMSSINKLMANPSLKINATDKEAIVNAWKAFNAEDMGNKFAALGKTFKAADYAIKANNIREKSIEGYQTGNWGPLMLEVESWVISGMASAVALSLFSFTLGSALIAFGLSATVVGFVGVVIAGAIGAFIDDKFVDELNHKIIK

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 42, 'R': 18, 'N': 31, 'D': 29, 'C': 0, 'Q': 16, 'E': 33, 'G': 47, 'H': 3, 'I': 37, 'L': 34, 'K': 27, 'M': 14, 'F': 14, 'P': 31, 'S': 46, 'T': 22, 'W': 8, 'Y': 13, 'V': 46

Frequencies of Amino Acids

'A': 8.22%, 'R': 3.52%, 'N': 6.07%, 'D': 5.68%, 'C': 0%, 'Q': 3.13%, 'E': 6.46%, 'G': 9.2%, 'H': 0.59%, 'I': 7.24%, 'L': 6.65%, 'K': 5.28%, 'M': 2.74%, 'F': 2.74%, 'P': 6.07%, 'S': 9%, 'T': 4.31%, 'W': 1.57%, 'Y': 2.54%, 'V': 9%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

273

Hydrophilic Amino Acid(s) Count

238

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	54897.1 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	88.513	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	40.273	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.18	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.673	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	4.551	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-16.677	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.297, 0.303, 0.241 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.068	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	63370, 63370	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Souvorov A, Agarwala R, Lipman DJ, et al. SKESA: strategic k-mer extension for scrupulous assemblies. Genome Biol. 2018;19(1):153. Published 2018 Oct 4. doi:10.1186/s13059-018-1540-z

PMID: 30286803

5.2 Protein Sequence Databases

UniProt: A0A085NWB2

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A0A085NWB2

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AAAGRJ010000034	GenBank \|\| EMBL
2.	AATIPO010000133	GenBank \|\| EMBL
3.	DABAZF010000084	GenBank \|\| EMBL
4.	MPGR01000003	GenBank \|\| EMBL
5.	RRNI01000161	GenBank \|\| EMBL

CCDS: Not found

RefSeq: WP_033805281.1

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR000293, IPR038283, IPR016128, IPR036302

PANTHER: Not found

PROSITE: PS00276

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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