AMPDB_513 | Cliotide T15

PEPTIDE SUMMARY

Cliotide T15

1 General Description

AMPDB ID: AMPDB_513

Protein Names: Cliotide T15 (Cyclotide cT15)

Protein Family: Cyclotide family; Moebius subfamily

Gene Name: Nil

Source Organism: Clitoria ternatea (Butterfly pea)

Protein Length: 29 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

GLPICGETCFKTKCYTKGCSCSYPVCKRN

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 0, 'R': 1, 'N': 1, 'D': 0, 'C': 6, 'Q': 0, 'E': 1, 'G': 3, 'H': 0, 'I': 1, 'L': 1, 'K': 4, 'M': 0, 'F': 1, 'P': 2, 'S': 2, 'T': 3, 'W': 0, 'Y': 2, 'V': 1

Frequencies of Amino Acids

'A': 0%, 'R': 3.45%, 'N': 3.45%, 'D': 0%, 'C': 20.69%, 'Q': 0%, 'E': 3.45%, 'G': 10.34%, 'H': 0%, 'I': 3.45%, 'L': 3.45%, 'K': 13.79%, 'M': 0%, 'F': 3.45%, 'P': 6.9%, 'S': 6.9%, 'T': 10.34%, 'W': 0%, 'Y': 6.9%, 'V': 3.45%

Missing Amino Acid(s)

A, D, H, M, Q, W

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

E, F, I, L, N, R, V

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	3190.79 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	36.897	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	40.293	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.259	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.317	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	8.617	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	3.625	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.207, 0.276, 0.069 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.103	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	2980, 3355	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Plant defense, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Nguyen KN, Nguyen GK, Nguyen PQ, et al. Immunostimulating and Gram-negative-specific antibacterial cyclotides from the butterfly pea (Clitoria ternatea). FEBS J. 2016;283(11):2067-90. Published 2016 Jun. doi:10.1111/febs.13720

PMID: 27007913

5.2 Protein Sequence Databases

UniProt: C0HJS2

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: C0HJS2

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR005535, IPR036146

PANTHER: Not found

PROSITE: PS51052

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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