AMPDB_504 | Preprofallaxidin-8

PEPTIDE SUMMARY

Preprofallaxidin-8

1 General Description

AMPDB ID: AMPDB_504

Protein Names: Preprofallaxidin-8 [Cleaved into: Fallaxidin-2.1; Fallaxidin-3.2; Fallaxidin-5.2]

Protein Family: Frog skin active peptide (FSAP) family; Brevinin subfamily

Gene Name: Nil

Source Organism: Litoria fallax (Eastern dwarf tree frog) (Hylomantis fallax)

Protein Length: 109 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MASLKKSLFLVLFLGLLSLSICEEQKRENEEDAEDENHEEESEEKRGLLDFAKHVIGIASKLGKRSEEKRFWPFMGKRSEEKRFWPFMGKRSEEKRFFRVLAKLGKLAK

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 6, 'R': 9, 'N': 2, 'D': 3, 'C': 1, 'Q': 1, 'E': 18, 'G': 7, 'H': 2, 'I': 3, 'L': 14, 'K': 15, 'M': 3, 'F': 9, 'P': 2, 'S': 9, 'T': 0, 'W': 2, 'Y': 0, 'V': 3

Frequencies of Amino Acids

'A': 5.5%, 'R': 8.26%, 'N': 1.83%, 'D': 2.75%, 'C': 0.92%, 'Q': 0.92%, 'E': 16.51%, 'G': 6.42%, 'H': 1.83%, 'I': 2.75%, 'L': 12.84%, 'K': 13.76%, 'M': 2.75%, 'F': 8.26%, 'P': 1.83%, 'S': 8.26%, 'T': 0%, 'W': 1.83%, 'Y': 0%, 'V': 2.75%

Missing Amino Acid(s)

T, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

C, Q

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	12864.9 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	74.312	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	80.176	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.742	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.914	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.706	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	3.147	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.284, 0.183, 0.376 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.101	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	11000, 11000	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

B.cereus (Gram-positive), E.cloacae (Gram-negative), E.faecalis (Gram-positive), L.innocua (Gram-positive), L.lactis (Gram-positive), M.luteus (Gram-negative), S.aureus (Gram-positive), S.epidermidis (Gram-positive), S.uberis (Gram-positive)

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Jackway RJ, Bowie JH, Bilusich D, et al. The fallaxidin peptides from the skin secretion of the Eastern Dwarf Tree Frog Litoria fallax. Sequence determination by positive and negative ion electrospray mass spectrometry: antimicrobial activity and cDNA cloning of the fallaxidins. Rapid Commun Mass Spectrom. 2008;22(20):3207-16. Published 2008 Oct. doi:10.1002/rcm.3723

PMID: 18803332

5.2 Protein Sequence Databases

UniProt: B5LUR0

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: B5LUR0

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	EU912535	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR004275

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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