AMPDB_484 | Pleurain-A1

PEPTIDE SUMMARY

Pleurain-A1

1 General Description

AMPDB ID: AMPDB_484

Protein Names: Pleurain-A1

Protein Family: Frog skin active peptide (FSAP) family; Pleurain subfamily

Gene Name: Nil

Source Organism: Nidirana pleuraden (Yunnan pond frog) (Babina pleuraden)

Protein Length: 69 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MFTLKKTLLLLFFLGTISISLCKQERDADEDDGRKMTEEEVKRSIITMTKEAKLPQLWKQIACRLYNTC

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 3, 'R': 4, 'N': 1, 'D': 4, 'C': 3, 'Q': 3, 'E': 6, 'G': 2, 'H': 0, 'I': 5, 'L': 10, 'K': 8, 'M': 3, 'F': 3, 'P': 1, 'S': 3, 'T': 7, 'W': 1, 'Y': 1, 'V': 1

Frequencies of Amino Acids

'A': 4.35%, 'R': 5.8%, 'N': 1.45%, 'D': 5.8%, 'C': 4.35%, 'Q': 4.35%, 'E': 8.7%, 'G': 2.9%, 'H': 0%, 'I': 7.25%, 'L': 14.49%, 'K': 11.59%, 'M': 4.35%, 'F': 4.35%, 'P': 1.45%, 'S': 4.35%, 'T': 10.14%, 'W': 1.45%, 'Y': 1.45%, 'V': 1.45%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

N, P, V, W, Y

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	8085.57 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	93.333	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	58.338	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.267	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.559	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	8.497	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	1.821	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.304, 0.101, 0.319 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.072	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	6990, 7115	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

C.albicans, E.coli (Gram-negative), H.pylori (Gram-negative), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Anti-candida, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytolysis, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Wang X, Song Y, Li J, et al. A new family of antimicrobial peptides from skin secretions of Rana pleuraden. Peptides. 2007;28(10):2069-74. Published 2007 Oct. doi:10.1016/j.peptides.2007.07.020

PMID: 17764786

5.2 Protein Sequence Databases

UniProt: A8DY01

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A8DY01

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	EF613243	GenBank \|\| EMBL
2.	EF613244	GenBank \|\| EMBL
3.	EF613245	GenBank \|\| EMBL
4.	EF613246	GenBank \|\| EMBL
5.	EF613247	GenBank \|\| EMBL
6.	EF613248	GenBank \|\| EMBL
7.	EF613249	GenBank \|\| EMBL
8.	EF613250	GenBank \|\| EMBL
9.	EF613251	GenBank \|\| EMBL
10.	EF613252	GenBank \|\| EMBL
11.	EF613253	GenBank \|\| EMBL
12.	EF613254	GenBank \|\| EMBL
13.	EF613255	GenBank \|\| EMBL
14.	EF613256	GenBank \|\| EMBL
15.	EF613257	GenBank \|\| EMBL
16.	EF613258	GenBank \|\| EMBL
17.	EF613259	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR018247, IPR004275

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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