AMPDB_482 | Basic phospholipase A2 BFPA

PEPTIDE SUMMARY

Basic phospholipase A2 BFPA

1 General Description

AMPDB ID: AMPDB_482

Protein Names: Basic phospholipase A2 BFPA (svPLA2) (EC 3.1.1.4) (Antimicrobial phospholipase A2) (Phosphatidylcholine 2-acylhydrolase)

Protein Family: Phospholipase A2 family; Group I subfamily; D49 sub-subfamily

Gene Name: Nil

Source Organism: Bungarus fasciatus (Banded krait) (Pseudoboa fasciata)

Protein Length: 145 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MNPAHLLVLLAVCVSLLGAANIPPQSLNLYQFKNMIQCAGTQLCVAYVKYGCYCGPGGTGTPLDQLDRCCQTHDHCYDNAKKFGNCIPYFKTYEYTCNKPDLTCTDAKGSCARNVCDCDRAAAICFAAAPYNLANFGINKETHCQ

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 16, 'R': 3, 'N': 11, 'D': 8, 'C': 16, 'Q': 7, 'E': 2, 'G': 10, 'H': 4, 'I': 5, 'L': 13, 'K': 8, 'M': 2, 'F': 5, 'P': 8, 'S': 3, 'T': 9, 'W': 0, 'Y': 9, 'V': 6

Frequencies of Amino Acids

'A': 11.03%, 'R': 2.07%, 'N': 7.59%, 'D': 5.52%, 'C': 11.03%, 'Q': 4.83%, 'E': 1.38%, 'G': 6.9%, 'H': 2.76%, 'I': 3.45%, 'L': 8.97%, 'K': 5.52%, 'M': 1.38%, 'F': 3.45%, 'P': 5.52%, 'S': 2.07%, 'T': 6.21%, 'W': 0%, 'Y': 6.21%, 'V': 4.14%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

A, C

Less Occurring Amino Acid(s)

E, M

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	15796.2 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	71.448	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	18.276	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.062	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.611	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	7.452	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	0.367	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.262, 0.221, 0.228 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.097	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	13410, 14410	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Hydrolase

4.4 Inhibitory Effect

Blood coagulation cascade inhibiting toxin

4.5 Other Biological Activity

Toxin, Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Xu C, Ma D, Yu H, et al. A bactericidal homodimeric phospholipases A2 from Bungarus fasciatus venom. Peptides. 2007;28(5):969-73. Published 2007 May. doi:10.1016/j.peptides.2007.02.008

PMID: 17383773

5.2 Protein Sequence Databases

UniProt: A6MEY4

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A6MEY4

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	DQ868667	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR001211, IPR033112, IPR016090, IPR036444, IPR033113

PANTHER: PTHR11716

PROSITE: PS00119, PS00118

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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