AMPDB_4728 | Ranatuerin-2CSa

PEPTIDE SUMMARY

Ranatuerin-2CSa

1 General Description

AMPDB ID: AMPDB_4728

Protein Names: Ranatuerin-2CSa

Protein Family: Frog skin active peptide (FSAP) family; Ranatuerin subfamily

Gene Name: Nil

Source Organism: Rana cascadae (Cascades frog)

Protein Length: 32 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

GILSSFKGVAKGVAKDLAGKLLETLKCKITGC

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 3, 'R': 0, 'N': 0, 'D': 1, 'C': 2, 'Q': 0, 'E': 1, 'G': 5, 'H': 0, 'I': 2, 'L': 5, 'K': 6, 'M': 0, 'F': 1, 'P': 0, 'S': 2, 'T': 2, 'W': 0, 'Y': 0, 'V': 2

Frequencies of Amino Acids

'A': 9.38%, 'R': 0%, 'N': 0%, 'D': 3.13%, 'C': 6.25%, 'Q': 0%, 'E': 3.13%, 'G': 15.63%, 'H': 0%, 'I': 6.25%, 'L': 15.63%, 'K': 18.75%, 'M': 0%, 'F': 3.13%, 'P': 0%, 'S': 6.25%, 'T': 6.25%, 'W': 0%, 'Y': 0%, 'V': 6.25%

Missing Amino Acid(s)

H, M, N, P, Q, R, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

D, E, F

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	3249.96 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	112.812	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	-4.197	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.444	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.582	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	10.138	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	3.874	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.313, 0.219, 0.281 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.031	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 125	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Conlon JM, Al-Dhaheri A, Al-Mutawa E, et al. Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group. Peptides. 2007;28(6):1268-74. Published 2007 Jun. doi:10.1016/j.peptides.2007.03.010

PMID: 17451843

Citation 2: Subasinghage AP, Conlon JM, Hewage CM, et al. Conformational analysis of the broad-spectrum antibacterial peptide, ranatuerin-2CSa: identification of a full length helix-turn-helix motif. Biochim Biophys Acta. 2008;1784(6):924-9. Published 2008 Jun. doi:10.1016/j.bbapap.2008.02.019

PMID: 18387372

5.2 Protein Sequence Databases

UniProt: V9GZ92

5.3 3D Structure Databases

	Sl. no.	PDB ID	Method	Resolution	Access Links	3D View

AlphaFoldDB: V9GZ92

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR012521

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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