AMPDB_4718 | Cathelicidin-related peptide Pt

AMPDB_4718 | Cathelicidin-related peptide Pt_CRAMP2

PEPTIDE SUMMARY

Cathelicidin-related peptide Pt_CRAMP2

1 General Description

AMPDB ID: AMPDB_4718

Protein Names: Cathelicidin-related peptide Pt_CRAMP2 (Cathelicidin-related antimicrobial peptide) (CRAMP) (Vipericidin)

Protein Family: Cathelicidin family

Gene Name: Nil

Source Organism: Pseudonaja textilis (Eastern brown snake)

Protein Length: 184 AA

Protein Existence: Evidence at transcript level

2 Protein Sequence & Composition

2.1 Sequence

MDGFFWKTWLVVAALAIGGTSSLPHKPLTYEEAVDLAVSTYNGKSGEESLYRLLEAVPPPKWDPLSESNQELNLTIKETVCLVAEERSLEECDFQDDGAVMGCTGYFFFGESPPVLVLTCEPLGEDEEQNQEEEEEEEKEEDEKDQPRRVKRFKKFFRKLKKSVKKRVKKFFKKPRVIGVTIPF

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 8, 'R': 8, 'N': 4, 'D': 9, 'C': 4, 'Q': 5, 'E': 27, 'G': 11, 'H': 1, 'I': 4, 'L': 17, 'K': 19, 'M': 2, 'F': 12, 'P': 12, 'S': 10, 'T': 9, 'W': 3, 'Y': 4, 'V': 15

Frequencies of Amino Acids

'A': 4.35%, 'R': 4.35%, 'N': 2.17%, 'D': 4.89%, 'C': 2.17%, 'Q': 2.72%, 'E': 14.67%, 'G': 5.98%, 'H': 0.54%, 'I': 2.17%, 'L': 9.24%, 'K': 10.33%, 'M': 1.09%, 'F': 6.52%, 'P': 6.52%, 'S': 5.43%, 'T': 4.89%, 'W': 1.63%, 'Y': 2.17%, 'V': 8.15%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

100

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	21117 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	72.5	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	58.166	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.593	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.953	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	4.604	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-9.116	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.299, 0.201, 0.293 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.103	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	22460, 22710	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

A.nidulans (Gram-positive), A.terreus (Not characterize), Bacillus (Gram-positive), C.albicans, C.globosum, P.pastoris

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-candida, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytotoxin, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Falcao CB, de La Torre BG, PÃ©rez-Peinado C, et al. Vipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers. Amino Acids. 2014;46(11):2561-71. Published 2014 Nov. doi:10.1007/s00726-014-1801-4

PMID: 25100358

5.2 Protein Sequence Databases

UniProt: U5KJM6

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: U5KJM6

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	JX948114	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR001894, IPR046350

PANTHER: PTHR10206

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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