AMPDB_47 | Macropin

PEPTIDE SUMMARY

Macropin

1 General Description

AMPDB ID: AMPDB_47

Protein Names: Macropin (MAC-1)

Protein Family: Nil

Gene Name: Nil

Source Organism: Macropis fulvipes (Solitary bee) (Megilla fulvipes)

Protein Length: 13 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

GFGMALKLLKKVL

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 1, 'R': 0, 'N': 0, 'D': 0, 'C': 0, 'Q': 0, 'E': 0, 'G': 2, 'H': 0, 'I': 0, 'L': 4, 'K': 3, 'M': 1, 'F': 1, 'P': 0, 'S': 0, 'T': 0, 'W': 0, 'Y': 0, 'V': 1

Frequencies of Amino Acids

'A': 7.69%, 'R': 0%, 'N': 0%, 'D': 0%, 'C': 0%, 'Q': 0%, 'E': 0%, 'G': 15.38%, 'H': 0%, 'I': 0%, 'L': 30.77%, 'K': 23.08%, 'M': 7.69%, 'F': 7.69%, 'P': 0%, 'S': 0%, 'T': 0%, 'W': 0%, 'Y': 0%, 'V': 7.69%

Missing Amino Acid(s)

C, D, E, H, I, N, P, Q, R, S, T, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

A, F, M, V

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	1417.86 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	150	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	-7.4	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	1.031	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.582	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	11.103	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	2.997	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.462, 0.154, 0.462 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.077	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 0	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

B.subtilis (Gram-positive), C.albicans, E.coli (Gram-negative), L.monocytogenes (Gram-positive), P.aeruginosa (Gram-negative), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Fungicide, Anti-candida, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: MonincovÃ¡ L, Veverka V, SlaninovÃ¡ J, et al. Structure-activity study of macropin, a novel antimicrobial peptide from the venom of solitary bee Macropis fulvipes (Hymenoptera: Melittidae). J Pept Sci. 2014;20(6):375-84. Published 2014 Jun. doi:10.1002/psc.2625

PMID: 24616110

Citation 2: Ko SJ, Kim MK, Bang JK, et al. Macropis fulvipes Venom component Macropin Exerts its Antibacterial and Anti-Biofilm Properties by Damaging the Plasma Membranes of Drug Resistant Bacteria. Sci Rep. 2017;7(1):16580. Published 2017 Nov 29. doi:10.1038/s41598-017-16784-6

PMID: 29185466

5.2 Protein Sequence Databases

UniProt: C0HL98

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: C0HL98

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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