AMPDB_4635 | Diptericin

PEPTIDE SUMMARY

Diptericin

1 General Description

AMPDB ID: AMPDB_4635

Protein Names: Diptericin

Protein Family: Attacin sarcotoxin-2 family

Gene Name: Nil

Source Organism: Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina)

Protein Length: 37 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

DLHIPPPDNKINWPQLSGGGGGSPKTGYDININAQQK

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 1, 'R': 0, 'N': 4, 'D': 3, 'C': 0, 'Q': 3, 'E': 0, 'G': 6, 'H': 1, 'I': 4, 'L': 2, 'K': 3, 'M': 0, 'F': 0, 'P': 5, 'S': 2, 'T': 1, 'W': 1, 'Y': 1, 'V': 0

Frequencies of Amino Acids

'A': 2.7%, 'R': 0%, 'N': 10.81%, 'D': 8.11%, 'C': 0%, 'Q': 8.11%, 'E': 0%, 'G': 16.22%, 'H': 2.7%, 'I': 10.81%, 'L': 5.41%, 'K': 8.11%, 'M': 0%, 'F': 0%, 'P': 13.51%, 'S': 5.41%, 'T': 2.7%, 'W': 2.7%, 'Y': 2.7%, 'V': 0%

Missing Amino Acid(s)

C, E, F, M, R, V

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

A, H, T, W, Y

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	3928.33 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	65.946	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	79.816	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-1.011	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.292	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	7.54	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	0.088	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.216, 0.459, 0.081 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.054	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	6990, 6990	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Acute, B.megaterium, B.subtilis (Gram-positive), C.bovis (Gram-positive), E.coli (Gram-negative), M.luteus (Gram-negative), P.aeruginosa (Gram-negative), P.rettgeri (Gram-negative), P.vulgaris (Gram-negative), S.aureus (Gram-positive), S.sonnei (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Ishikawa M, Kubo T, Natori S, et al. Purification and characterization of a diptericin homologue from Sarcophaga peregrina (flesh fly). Biochem J. 1992;287 ( Pt 2)(Pt 2):573-8. Published 1992 Oct 15. doi:10.1042/bj2870573

PMID: 1445217

5.2 Protein Sequence Databases

UniProt: Q9TWW2

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: Q9TWW2

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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