AMPDB_4602 | Beta-defensin 103A

PEPTIDE SUMMARY

Beta-defensin 103A

1 General Description

AMPDB ID: AMPDB_4602

Protein Names: Beta-defensin 103A (Beta-defensin 3) (BD-3) (DEFB-3) (cBD-3) (Defensin; beta 103) (Defensin; beta 103A)

Protein Family: Beta-defensin family

Gene Name: DEFB103A DEFB103 DEFB3

Source Organism: Pan troglodytes (Chimpanzee)

Protein Length: 67 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MRIHYLLFALLFLFLVPVPGHGGIINTLQKYYCRVRGGRCAVLTCLPKEEQIGKCSTRGRKCCRRKK

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 2, 'R': 8, 'N': 1, 'D': 0, 'C': 6, 'Q': 2, 'E': 2, 'G': 7, 'H': 2, 'I': 4, 'L': 9, 'K': 6, 'M': 1, 'F': 3, 'P': 3, 'S': 1, 'T': 3, 'W': 0, 'Y': 3, 'V': 4

Frequencies of Amino Acids

'A': 2.99%, 'R': 11.94%, 'N': 1.49%, 'D': 0%, 'C': 8.96%, 'Q': 2.99%, 'E': 2.99%, 'G': 10.45%, 'H': 2.99%, 'I': 5.97%, 'L': 13.43%, 'K': 8.96%, 'M': 1.49%, 'F': 4.48%, 'P': 4.48%, 'S': 1.49%, 'T': 4.48%, 'W': 0%, 'Y': 4.48%, 'V': 5.97%

Missing Amino Acid(s)

D, W

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

M, N, S

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	7711.39 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	95.97	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	50.296	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.003	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.631	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	10.673	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	11.807	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.343, 0.179, 0.209 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.09	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	4470, 4845	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria and Gram Positive Bacteria

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Defensin, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Patil AA, Cai Y, Sang Y, et al. Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. Physiol Genomics. 2005;23(1):5-17. Published 2005 Sep 21. doi:10.1152/physiolgenomics.00104.2005

PMID: 16033865

Citation 2: Semple CA, Maxwell A, Gautier P, et al. The complexity of selection at the major primate beta-defensin locus. BMC Evol Biol. 2005;5:32. Published 2005 May 18. doi:10.1186/1471-2148-5-32

PMID: 15904491

5.2 Protein Sequence Databases

UniProt: Q95JD2

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: Q95JD2

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	DQ012056	GenBank \|\| EMBL
2.	AM410103	GenBank \|\| EMBL
3.	AY033883	GenBank \|\| EMBL
4.	AY831729	GenBank \|\| EMBL

CCDS: Not found

RefSeq: NP_001123222.1

5.5 Protein-Protein Interaction Databases

STRING: 9598.ENSPTRP00000034200

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR001855

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: ENSGT00530000064280

KEGG: ptr:450106

5.9 Phylogenomic Databases

GeneTree: ENSGT00530000064280

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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