AMPDB_45409 | HNH endonuclease

PEPTIDE SUMMARY

HNH endonuclease

1 General Description

AMPDB ID: AMPDB_45409

Protein Names: HNH endonuclease (S-type pyocin domain-containing protein)

Protein Family: Colicin pyosin nuclease family

Gene Name: CTQ69_17810 GBY29_05970 JMJ85_06710 PG27_09265

Source Organism: Salmonella diarizonae

Protein Length: 238 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MVWNSEHNRYEFTPAHGADGPLITWTPERPEGSDLPSHTGSDIKSIDQATILVTPIPDGKDEYTTPPFPVPEERDLNDYILVFPADSGIKPIYVYLKDDPRDQAGTASGNGSQIETGQKWLDLSVTNNGEGAKIPSNIADKLRGRHYDSFRKSREDLWLEISKDPELSKQFSNGNIEAMQEGKAPTAPFAGHYVGPKQVIKKFEIHHIKPIEEGGGVYDIDNLRITTPKLHKFIHYGE

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 12, 'R': 9, 'N': 10, 'D': 19, 'C': 0, 'Q': 7, 'E': 18, 'G': 21, 'H': 9, 'I': 20, 'L': 14, 'K': 17, 'M': 2, 'F': 8, 'P': 21, 'S': 15, 'T': 14, 'W': 4, 'Y': 9, 'V': 9

Frequencies of Amino Acids

'A': 5.04%, 'R': 3.78%, 'N': 4.2%, 'D': 7.98%, 'C': 0%, 'Q': 2.94%, 'E': 7.56%, 'G': 8.82%, 'H': 3.78%, 'I': 8.4%, 'L': 5.88%, 'K': 7.14%, 'M': 0.84%, 'F': 3.36%, 'P': 8.82%, 'S': 6.3%, 'T': 5.88%, 'W': 1.68%, 'Y': 3.78%, 'V': 3.78%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

G, P

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

111

Hydrophilic Amino Acid(s) Count

127

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	26590.6 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	71.723	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	46.733	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.735	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.639	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	5.171	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-10.156	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.269, 0.282, 0.193 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.088	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	35410, 35410	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Endonuclease, Hydrolase, Nuclease

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Souvorov A, Agarwala R, Lipman DJ, et al. SKESA: strategic k-mer extension for scrupulous assemblies. Genome Biol. 2018;19(1):153. Published 2018 Oct 4. doi:10.1186/s13059-018-1540-z

PMID: 30286803

5.2 Protein Sequence Databases

UniProt: A0A3Z2FVC1

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A0A3Z2FVC1

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AAGLNK010000008	GenBank \|\| EMBL
2.	AAIBIC010000023	GenBank \|\| EMBL
3.	DAAGPR010000009	GenBank \|\| EMBL
4.	CP078142	GenBank \|\| EMBL

CCDS: Not found

RefSeq: WP_070802041.1

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR037146, IPR044925, IPR003615, IPR003060, IPR016128, IPR036302

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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