AMPDB_4535 | Beta-defensin 38

PEPTIDE SUMMARY

Beta-defensin 38

1 General Description

AMPDB ID: AMPDB_4535

Protein Names: Beta-defensin 38 (BD-38) (mBD-38) (Defensin; beta 38)

Protein Family: Beta-defensin family

Gene Name: Defb38

Source Organism: Mus musculus (Mouse)

Protein Length: 63 AA

Protein Existence: Evidence at transcript level

2 Protein Sequence & Composition

2.1 Sequence

MKISCFLLLILSLYFFQINQAIGPDTKKCVQRKNACHYFECPWLYYSVGTCYKGKGKCCQKRY

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 2, 'R': 2, 'N': 2, 'D': 1, 'C': 7, 'Q': 4, 'E': 1, 'G': 4, 'H': 1, 'I': 4, 'L': 6, 'K': 8, 'M': 1, 'F': 4, 'P': 2, 'S': 3, 'T': 2, 'W': 1, 'Y': 6, 'V': 2

Frequencies of Amino Acids

'A': 3.17%, 'R': 3.17%, 'N': 3.17%, 'D': 1.59%, 'C': 11.11%, 'Q': 6.35%, 'E': 1.59%, 'G': 6.35%, 'H': 1.59%, 'I': 6.35%, 'L': 9.52%, 'K': 12.7%, 'M': 1.59%, 'F': 6.35%, 'P': 3.17%, 'S': 4.76%, 'T': 3.17%, 'W': 1.59%, 'Y': 9.52%, 'V': 3.17%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

D, E, H, M, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	7442.9 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	74.286	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	38.06	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.084	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.551	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.313	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	7.65	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.365, 0.175, 0.159 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.175	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	14440, 14815	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative), E.faecium (Gram-positive), P.aeruginosa (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Defensin, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Zaballos A, Villares R, Albar JP, et al. Identification on mouse chromosome 8 of new beta-defensin genes with regionally specific expression in the male reproductive organ. J Biol Chem. 2004;279(13):12421-6. Published 2004 Mar 26. doi:10.1074/jbc.M307697200

PMID: 14718547

5.2 Protein Sequence Databases

UniProt: Q7TNV7

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: Q7TNV7

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AJ575424	GenBank \|\| EMBL
2.	AJ578471	GenBank \|\| EMBL

CCDS: CCDS40248.1

RefSeq: NP_898857.1

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR001855

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: ENSGT01050000245197

KEGG: mmu:360212

5.9 Phylogenomic Databases

GeneTree: ENSGT01050000245197

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Q7TNV7

Download