AMPDB_449 | Dermaseptin-PH

PEPTIDE SUMMARY

Dermaseptin-PH

1 General Description

AMPDB ID: AMPDB_449

Protein Names: Dermaseptin-PH (DRS-PH)

Protein Family: Frog skin active peptide (FSAP) family

Gene Name: DMP-PH

Source Organism: Pithecopus hypochondrialis (Orange-legged leaf frog) (Phyllomedusa hypochondrialis)

Protein Length: 70 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MDILKKSLFLILFLGVVSLSICEEEKRENEEEMEQDDEQSEMKRALWKEVLKNAGKAALNEINNLVQGGQ

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 4, 'R': 2, 'N': 5, 'D': 3, 'C': 1, 'Q': 4, 'E': 12, 'G': 4, 'H': 0, 'I': 4, 'L': 10, 'K': 7, 'M': 3, 'F': 2, 'P': 0, 'S': 4, 'T': 0, 'W': 1, 'Y': 0, 'V': 4

Frequencies of Amino Acids

'A': 5.71%, 'R': 2.86%, 'N': 7.14%, 'D': 4.29%, 'C': 1.43%, 'Q': 5.71%, 'E': 17.14%, 'G': 5.71%, 'H': 0%, 'I': 5.71%, 'L': 14.29%, 'K': 10%, 'M': 4.29%, 'F': 2.86%, 'P': 0%, 'S': 5.71%, 'T': 0%, 'W': 1.43%, 'Y': 0%, 'V': 5.71%

Missing Amino Acid(s)

H, P, T, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

C, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	8024.18 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	100.286	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	64.844	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.46	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.659	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	4.26	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-6.043	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.3, 0.186, 0.414 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.043	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	5500, 5500	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Candida albicans

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Fungicide, Anti-candida

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Anti-cancer, Cytotoxin, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Li M, Xi X, Ma C, et al. A Novel Dermaseptin Isolated from the Skin Secretion of Phyllomedusa tarsius and Its Cationicity-Enhanced Analogue Exhibiting Effective Antimicrobial and Anti-Proliferative Activities. Biomolecules. 2019;9(10). Published 2019 Oct 18. doi:10.3390/biom9100628

PMID: 31635388

5.2 Protein Sequence Databases

UniProt: A0A2U8JCR5

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A0A2U8JCR5

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	MF805718	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR004275, IPR016322

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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