AMPDB_4477 | Propionicin-F

PEPTIDE SUMMARY

Propionicin-F

1 General Description

AMPDB ID: AMPDB_4477

Protein Names: Propionicin-F

Protein Family: Nil

Gene Name: pcfA

Source Organism: Propionibacterium freudenreichii subsp. freudenreichii

Protein Length: 255 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MNTKAVNLKSENTTKLVSYLTENQLDEFIRRIRIDGALVEEVSQNAKQALDNTGLNGWINTDCDEGLLSDFISKIASARWIPLAESIRPAVTDRDKYRVSCWFYQGMNIAIYANIGGVANIIGYTEAAVATLLGAVVAVAPVVPGTPTPPKDKSSQYKEVPLAVRLSETYHEEGVRGLFDELNYSESRMISTLRRASTDGVLINSWNDGQDTILLKKYNFQDLQLTVRSRIVGNQTIIEECKITDGRKTLSDETV

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 19, 'R': 15, 'N': 16, 'D': 16, 'C': 3, 'Q': 9, 'E': 17, 'G': 16, 'H': 1, 'I': 20, 'L': 23, 'K': 13, 'M': 3, 'F': 5, 'P': 8, 'S': 18, 'T': 20, 'W': 4, 'Y': 9, 'V': 20

Frequencies of Amino Acids

'A': 7.45%, 'R': 5.88%, 'N': 6.27%, 'D': 6.27%, 'C': 1.18%, 'Q': 3.53%, 'E': 6.67%, 'G': 6.27%, 'H': 0.39%, 'I': 7.84%, 'L': 9.02%, 'K': 5.1%, 'M': 1.18%, 'F': 1.96%, 'P': 3.14%, 'S': 7.06%, 'T': 7.84%, 'W': 1.57%, 'Y': 3.53%, 'V': 7.84%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

118

Hydrophilic Amino Acid(s) Count

137

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	28310 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	95.961	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	46.694	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.253	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.809	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	4.875	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-5.071	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.318, 0.227, 0.243 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.071	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	35410, 35535	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

P.jensenii

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Brede DA, Faye T, Johnsborg O, et al. Molecular and genetic characterization of propionicin F, a bacteriocin from Propionibacterium freudenreichii. Appl Environ Microbiol. 2004;70(12):7303-10. Published 2004 Dec. doi:10.1128/AEM.70.12.7303-7310.2004

PMID: 15574930

5.2 Protein Sequence Databases

UniProt: Q6E3K9

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: Q6E3K9

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AY587566	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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