AMPDB_4455 | Arenicin-2

PEPTIDE SUMMARY

Arenicin-2

1 General Description

AMPDB ID: AMPDB_4455

Protein Names: Arenicin-2

Protein Family: Nil

Gene Name: Nil

Source Organism: Arenicola marina (Lugworm) (Lumbricus marinus)

Protein Length: 202 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MTSTQSVAVYATLILAIFCFNDIHCDPIAEARAAAFGEREARSAGEWKQFDVNGEKVEVNEQENREIIRQAGGDGVEGSVMVIDHAKGLIIWSIPRAGECYLIGGVDKQLPDAQELLHYFRSAQGSADGEGVQSALDYVKAEDRPVTDLNLLAPEVREACQGKSVYWLEKSSGDNNEPEKRRWCVYAYVRIRGVLVRYRRCW

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 21, 'R': 16, 'N': 7, 'D': 12, 'C': 6, 'Q': 9, 'E': 19, 'G': 17, 'H': 3, 'I': 12, 'L': 13, 'K': 8, 'M': 2, 'F': 5, 'P': 6, 'S': 11, 'T': 4, 'W': 5, 'Y': 8, 'V': 18

Frequencies of Amino Acids

'A': 10.4%, 'R': 7.92%, 'N': 3.47%, 'D': 5.94%, 'C': 2.97%, 'Q': 4.46%, 'E': 9.41%, 'G': 8.42%, 'H': 1.49%, 'I': 5.94%, 'L': 6.44%, 'K': 3.96%, 'M': 0.99%, 'F': 2.48%, 'P': 2.97%, 'S': 5.45%, 'T': 1.98%, 'W': 2.48%, 'Y': 3.96%, 'V': 8.91%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

103

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	22614.5 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	84.505	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	46.358	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.35	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.634	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	4.858	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-7.071	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.302, 0.203, 0.272 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.089	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	39420, 39795	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative), L.monocytogenes (Gram-positive), P.mirabilis (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Fungicide, Anti-candida, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Ovchinnikova TV, Aleshina GM, Balandin SV, et al. Purification and primary structure of two isoforms of arenicin, a novel antimicrobial peptide from marine polychaeta Arenicola marina. FEBS Lett. 2004;577(1-2):209-14. Published 2004 Nov 5. doi:10.1016/j.febslet.2004.10.012

PMID: 15527787

Citation 2: AndrÃ¤ J, Jakovkin I, GrÃ¶tzinger J, et al. Structure and mode of action of the antimicrobial peptide arenicin. Biochem J. 2008;410(1):113-22. Published 2008 Feb 15. doi:10.1042/BJ20071051

PMID: 17935487

5.2 Protein Sequence Databases

UniProt: Q5SC59

5.3 3D Structure Databases

	Sl. no.	PDB ID	Method	Resolution	Access Links	3D View

AlphaFoldDB: Q5SC59

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AY684857	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR007084

PANTHER: Not found

PROSITE: PS50869

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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