AMPDB_4455 | Arenicin-2
PEPTIDE SUMMARY
Arenicin-2
1 General Description
AMPDB ID: AMPDB_4455
Protein Names: Arenicin-2
Protein Family: Nil
Gene Name: Nil
Protein Length: 202 AA
Protein Existence: Evidence at protein level
2 Protein Sequence & Composition
2.1 Sequence
MTSTQSVAVYATLILAIFCFNDIHCDPIAEARAAAFGEREARSAGEWKQFDVNGEKVEVNEQENREIIRQAGGDGVEGSVMVIDHAKGLIIWSIPRAGECYLIGGVDKQLPDAQELLHYFRSAQGSADGEGVQSALDYVKAEDRPVTDLNLLAPEVREACQGKSVYWLEKSSGDNNEPEKRRWCVYAYVRIRGVLVRYRRCW
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 21, 'R': 16, 'N': 7, 'D': 12, 'C': 6, 'Q': 9, 'E': 19, 'G': 17, 'H': 3, 'I': 12, 'L': 13, 'K': 8, 'M': 2, 'F': 5, 'P': 6, 'S': 11, 'T': 4, 'W': 5, 'Y': 8, 'V': 18
Frequencies of Amino Acids
'A': 10.4%, 'R': 7.92%, 'N': 3.47%, 'D': 5.94%, 'C': 2.97%, 'Q': 4.46%, 'E': 9.41%, 'G': 8.42%, 'H': 1.49%, 'I': 5.94%, 'L': 6.44%, 'K': 3.96%, 'M': 0.99%, 'F': 2.48%, 'P': 2.97%, 'S': 5.45%, 'T': 1.98%, 'W': 2.48%, 'Y': 3.96%, 'V': 8.91%
Missing Amino Acid(s)
No Amino Acid(s) are missing in this protein
Most Occurring Amino Acid(s)
A
Less Occurring Amino Acid(s)
M
Hydrophobic Amino Acid(s) Count
99
Hydrophilic Amino Acid(s) Count
103
Basic Amino Acid(s) Count
31
Acidic Amino Acid(s) Count
27
Modified Amino Acid(s) Count
0
Modified Amino Acid(s) Frequencies
0
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 22614.5 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 84.505 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 46.358 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) -0.35 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.634 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 4.858 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) -7.071 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.302, 0.203, 0.272 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.089 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 39420, 39795 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
E.coli (Gram-negative), L.monocytogenes (Gram-positive), P.mirabilis (Gram-negative)
4.2 Antimicrobial Activity
Antibiotic, Antimicrobial, Fungicide, Anti-candida, Anti-gram-negative, Anti-gram-Positive
4.3 Enzymatic Activity
Not found
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Non-hemolytic, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: Ovchinnikova TV, Aleshina GM, Balandin SV, et al. Purification and primary structure of two isoforms of arenicin, a novel antimicrobial peptide from marine polychaeta Arenicola marina. FEBS Lett. 2004;577(1-2):209-14. Published 2004 Nov 5. doi:10.1016/j.febslet.2004.10.012
PMID: 15527787
Citation 2: Andrä J, Jakovkin I, Grötzinger J, et al. Structure and mode of action of the antimicrobial peptide arenicin. Biochem J. 2008;410(1):113-22. Published 2008 Feb 15. doi:10.1042/BJ20071051
PMID: 17935487
5.2 Protein Sequence Databases
UniProt: Q5SC59
5.3 3D Structure Databases
Sl. no. PDB ID Method Resolution Access Links 3D View
AlphaFoldDB: Q5SC59
5.4 Nucleotide Sequence Databases
Sl. no. Accession(s) Access Link(s)
1. AY684857 GenBank || EMBL
CCDS: Not found
RefSeq: Not found
5.5 Protein-Protein Interaction Databases
STRING: Not found
IntAct: Not found
MINT: Not found
DIP: Not found
BioGRID: Not found
5.6 Ligand Databases
BindingDB: Not found
DrugBank: Not found
ChEMBL: Not found
5.7 Family & Domain Databases
InterPro: IPR007084
PANTHER: Not found
PROSITE: PS50869
5.8 Genome Annotation Databases
Ensembl: Not found
KEGG: Not found
5.9 Phylogenomic Databases
GeneTree: Not found
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: Not found




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