AMPDB_4440 | Cecropin-P4

PEPTIDE SUMMARY

Cecropin-P4

1 General Description

AMPDB ID: AMPDB_4440

Protein Names: Cecropin-P4

Protein Family: Cecropin family

Gene Name: ASCEC-4

Source Organism: Ascaris suum (Pig roundworm) (Ascaris lumbricoides)

Protein Length: 74 AA

Protein Existence: Evidence at transcript level

2 Protein Sequence & Composition

2.1 Sequence

MFLMYLLVQTTESSWLSKTYKKLENSAKKRISEGVAIAILGGLRHRRSVAHQEEASLHVKTDELPSPDTVREQL

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 5, 'R': 5, 'N': 1, 'D': 2, 'C': 0, 'Q': 3, 'E': 7, 'G': 3, 'H': 3, 'I': 3, 'L': 10, 'K': 6, 'M': 2, 'F': 1, 'P': 2, 'S': 8, 'T': 5, 'W': 1, 'Y': 2, 'V': 5

Frequencies of Amino Acids

'A': 6.76%, 'R': 6.76%, 'N': 1.35%, 'D': 2.7%, 'C': 0%, 'Q': 4.05%, 'E': 9.46%, 'G': 4.05%, 'H': 4.05%, 'I': 4.05%, 'L': 13.51%, 'K': 8.11%, 'M': 2.7%, 'F': 1.35%, 'P': 2.7%, 'S': 10.81%, 'T': 6.76%, 'W': 1.35%, 'Y': 2.7%, 'V': 6.76%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

F, N, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	8423.7 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	94.865	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	67.723	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.415	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.591	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.727	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	2.281	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.297, 0.189, 0.324 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.054	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	8480, 8480	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria and Gram Positive Bacteria

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Pillai A, Ueno S, Zhang H, et al. Cecropin P1 and novel nematode cecropins: a bacteria-inducible antimicrobial peptide family in the nematode Ascaris suum. Biochem J. 2005;390(Pt 1):207-14. Published 2005 Aug 15. doi:10.1042/BJ20050218

PMID: 15850460

5.2 Protein Sequence Databases

UniProt: Q5H7N4

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: Q5H7N4

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AB186035	GenBank \|\| EMBL
2.	AB186039	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR000875

PANTHER: Not found

PROSITE: PS00268

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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