AMPDB_4438 | Putative antimicrobial peptide clone 4

PEPTIDE SUMMARY

Putative antimicrobial peptide clone 4

1 General Description

AMPDB ID: AMPDB_4438

Protein Names: Putative antimicrobial peptide clone 4 (Non-disulfide-bridged peptide 4.23-like) (NDBP-4.23-like)

Protein Family: Non-disulfide-bridged peptide (NDBP) superfamily; Short antimicrobial peptide (group 4) family

Gene Name: Nil

Source Organism: Tityus costatus (Brazilian scorpion)

Protein Length: 73 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MQMKYLIPIFFLVLIVADHCHAFLGMIPGLIGGLISAFKGRRKRDITSQIEQYRNLQKREAELEDILANLPVY

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 5, 'R': 5, 'N': 2, 'D': 3, 'C': 1, 'Q': 4, 'E': 4, 'G': 5, 'H': 2, 'I': 9, 'L': 10, 'K': 4, 'M': 3, 'F': 4, 'P': 3, 'S': 2, 'T': 1, 'W': 0, 'Y': 3, 'V': 3

Frequencies of Amino Acids

'A': 6.85%, 'R': 6.85%, 'N': 2.74%, 'D': 4.11%, 'C': 1.37%, 'Q': 5.48%, 'E': 5.48%, 'G': 6.85%, 'H': 2.74%, 'I': 12.33%, 'L': 13.7%, 'K': 5.48%, 'M': 4.11%, 'F': 5.48%, 'P': 4.11%, 'S': 2.74%, 'T': 1.37%, 'W': 0%, 'Y': 4.11%, 'V': 4.11%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

C, T

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	8418.03 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	120.274	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	49.051	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.226	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.505	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.159	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	2.123	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.397, 0.164, 0.301 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.096	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	4470, 4470	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

C.albicans, Candida spp., Cryptococcus neoformans, E.faecalis (Gram-positive), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Fungicide, Anti-MRSA, Anti-biofilm, Anti-candida, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Anti-cancer, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Diego-GarcÃa E, Batista CV, GarcÃa-GÃ³mez BI, et al. The Brazilian scorpion Tityus costatus Karsch: genes, peptides and function. Toxicon. 2005;45(3):273-83. Published 2005 Mar 1. doi:10.1016/j.toxicon.2004.10.014

PMID: 15683865

Citation 2: Guilhelmelli F, Vilela N, Smidt KS, et al. Activity of Scorpion Venom-Derived Antifungal Peptides against Planktonic Cells of Candida spp. and Cryptococcus neoformans and Candida albicans Biofilms. Front Microbiol. 2016;7:1844. Published 2016. doi:10.3389/fmicb.2016.01844

PMID: 27917162

5.2 Protein Sequence Databases

UniProt: Q5G8B5

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: Q5G8B5

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AY740686	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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