AMPDB_4401 | Colicin-K

PEPTIDE SUMMARY

Colicin-K

1 General Description

AMPDB ID: AMPDB_4401

Protein Names: Colicin-K

Protein Family: Channel forming colicin family

Gene Name: cka

Source Organism: Escherichia coli

Protein Length: 548 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MAKELSGYGPTAGESMGGTGANLNQQGGNNNSNSGVHWGGGSGHGNNGGQGNSNSSGSTSTVMKTGESYLTPWGDVVINNDGLPVMNGIVMTEENSTLVDNPFGGVSRVLNSLISDMPSLFAESSGNNNNNTASVNTAPTNAQVSDMDKSSKVVSNVINEKQKQKNKIATQISEKQKKIEEMKKVFKHHSYHGITDLERDVDELQKKSNQLDADISKLNSYKNTLQSKIGDVNKQKEAEEKARENAEVAEHETLNEEKQAVAEAEKRLAEAKAELAKAESDVQSKQATVSRVAGELENAQKSVDVKVTGFPGWRDVQKKLQRQLEAKQAEYSAVENELKNAVSFRDGKAAEVKEAEQKLKEAQDALEKSQIKDAVDTMVGFYQYITEQYGEKYAKIAQDLAEKSKGKKIQGVDEALAAFEKYKNVLDKKFSKVDRDAIFNALESVNYDELSKNLTKISKSLKITSRVSFLYDVGSDFKNAIETGNWRPLFVTLEKSAVDVGVAKIVALMFSFIVGVPLGFWGIAIVTGIVSSYIGDDELSKLNELLGI

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 47, 'R': 11, 'N': 42, 'D': 30, 'C': 0, 'Q': 27, 'E': 48, 'G': 44, 'H': 6, 'I': 25, 'L': 38, 'K': 58, 'M': 10, 'F': 15, 'P': 9, 'S': 50, 'T': 24, 'W': 5, 'Y': 13, 'V': 46

Frequencies of Amino Acids

'A': 8.58%, 'R': 2.01%, 'N': 7.66%, 'D': 5.47%, 'C': 0%, 'Q': 4.93%, 'E': 8.76%, 'G': 8.03%, 'H': 1.09%, 'I': 4.56%, 'L': 6.93%, 'K': 10.58%, 'M': 1.82%, 'F': 2.74%, 'P': 1.64%, 'S': 9.12%, 'T': 4.38%, 'W': 0.91%, 'Y': 2.37%, 'V': 8.39%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

239

Hydrophilic Amino Acid(s) Count

309

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	59661.7 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	77.756	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	20.845	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.591	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.795	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	5.374	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-8.386	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.259, 0.265, 0.261 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.06	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	46870, 46870	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Pilsl H, Braun V, Braun V. Strong function-related homology between the pore-forming colicins K and 5. J Bacteriol. 1995;177(23):6973-7. Published 1995 Dec. doi:10.1128/jb.177.23.6973-6977.1995

PMID: 7592493

5.2 Protein Sequence Databases

UniProt: Q47502

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: Q47502

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	X87834	GenBank \|\| EMBL
2.	U27452	GenBank \|\| EMBL

CCDS: Not found

RefSeq: WP_011264160.1, YP_214172.1

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR000293, IPR038283

PANTHER: Not found

PROSITE: PS00276

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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